# Saylor Innovations Bioinformatics — Genetic Variant Clinical Significance (ClinVar)

> Saylor Innovations Bioinformatics — Genetic Variant Clinical Significance (ClinVar) is a paid API for AI agents from saylorinnovations.com, paid per call via x402, $0.003/call, status unknown (last checked 2026-10-01).

Returns clinical significance, review status, conditions, genes, and molecular details for a genetic variant queried by rsID, ClinVar VCV ID, or HGVS notation, sourced from NCBI ClinVar.

## Facts

- Endpoint: GET https://saylorinnovations.com/api/bio/variant/:id?utm_source=zero.xyz
- Price: $0.003/call
- Payment: x402
- Status: unknown
- Last checked: 2026-10-01
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/saylor-innovations-bioinformatics-genetic-variant-clinical-5f629881
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_sU-bBmvLGspfCVFU514nC

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability saylor-innovations-bioinformatics-genetic-variant-clinical-5f629881
```

Example prompt: Look up the clinical significance of the genetic variant rs121912666 in ClinVar — I need the pathogenicity classification, review star rating, associated conditions, and any protein change noted.

## When to prefer this

Choose this endpoint when you need structured, parsed ClinVar clinical significance data for a specific genetic variant without setting up your own NCBI API integration. Ideal for bioinformatics pipelines, genetic reporting tools, or research agents that need fast, per-variant lookups with star-rated review status. Prefer this over raw ClinVar API access when you want a clean JSON response with the best-reviewed record surfaced first.

## Known failure modes

- Variant ID not found in ClinVar — returns found: false with empty records
- Malformed rsID, VCV, or HGVS notation causes a 400 or empty result
- Variant exists in ClinVar but has no reviewed submissions — returns uncertain or no-assertion record
- ClinVar data may be outdated relative to latest NCBI releases — last evaluated date indicates data freshness
- Rare or novel variants may have no ClinVar entry at all

## How this service works

Genetic Variant Clinical Significance (ClinVar). Genetic variant clinical significance from ClinVar by rsID, ClinVar id (VCV) or HGVS: pathogenic / benign / uncertain classification, review status with 0-4 stars, conditions, genes, molecular consequence, protein change and last evaluated date, best-reviewed record first. NCBI ClinVar, public domain; not medical advice.

## Output

Returns a JSON object with a 'found' boolean; if found, includes a 'primary' record (best-reviewed) and a 'records' array. Each record contains clinical significance (pathogenic/benign/uncertain/conflicting), review status with 0–4 star rating, associated disease conditions, gene symbols, molecular consequence, protein change, and last evaluated date.

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "$schema": "https://json-schema.org/draft/2020-12/schema",
 "required": [
  "input"
 ],
 "properties": {
  "input": {
   "type": "object",
   "required": [
    "type",
    "method",
    "pathParams"
   ],
   "properties": {
    "type": {
     "type": "string",
     "const": "http"
    },
    "method": {
     "enum": [
      "GET",
      "POST",
      "PUT",
      "PATCH",
      "DELETE",
      "HEAD"
     ],
     "type": "string"
    },
    "pathParams": {
     "type": "object",
     "required": [
      "id"
     ],
     "properties": {
      "id": {
       "type": "string"
      }
     }
    }
   },
   "additionalProperties": false
  },
  "output": {
   "type": "object",
   "required": [
    "type"
   ],
   "properties": {
    "type": {
     "type": "string",
     "const": "json"
    },
    "example": {
     "type": "object",
     "required": [
      "found"
     ],
     "properties": {
      "found": {
       "type": "boolean"
      },
      "primary": {
       "type": "object"
      },
      "records": {
       "type": "array",
       "items": {
        "type": "object"
       }
      }
     }
    }
   }
  }
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/saylor-innovations-bioinformatics-genetic-variant-clinical-5f629881/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from saylorinnovations.com](https://www.zero.xyz/host/saylorinnovations.com/llms.txt)