# Saylor Innovations Gene & Drug Target Lookup

> Saylor Innovations Gene & Drug Target Lookup is a paid API for AI agents from saylorinnovations.com, paid per call via x402, $0.01/call, status unknown (last checked 2026-10-17).

Looks up gene and drug-target information from Open Targets, returning Ensembl ID, genomic location, function, tractability by modality, and top associated diseases with scores

## Facts

- Endpoint: GET https://saylorinnovations.com/api/bio/target-search?utm_source=zero.xyz
- Price: $0.01/call
- Payment: x402
- Status: unknown
- Last checked: 2026-10-17
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/saylor-innovations-gene-drug-target-lookup-5c70de03
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_qj24SEsuRAdCvo0FgScUM

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability saylor-innovations-gene-drug-target-lookup-5c70de03
```

Example prompt: Can you look up EGFR for me — I need its Ensembl ID, genomic location, gene function, which drug modalities can target it, and the top diseases it's associated with according to Open Targets?

## When to prefer this

Choose this endpoint when you need structured bioinformatics data on a gene or protein drug target, including disease associations and drug tractability by modality, sourced from Open Targets. Prefer it over general web search when you need machine-readable, scored data for programmatic use in drug discovery or genomics workflows. Best for queries where you have a gene symbol, common name, or Ensembl ID.

## Known failure modes

- Gene symbol not found or misspelled returns empty top_match or lower-confidence other_matches
- Ambiguous query (common name matching multiple genes) may return unexpected top_match
- Ensembl ID format errors result in no match
- Open Targets upstream data gaps may mean some tractability modalities are absent
- Rate limiting or payment failure returns HTTP 402

## How this service works

Gene and drug-target lookup from Open Targets - Ensembl id, location, function, tractability by modality and top associated diseases with scores

## Output

Returns a top_match object containing the gene's Ensembl ID, genomic location, biological function, tractability scores by drug modality (e.g. small molecule, antibody, PROTAC), and a ranked list of associated diseases with confidence scores. Also returns any other_matches for ambiguous queries, the canonical URL, and the data source attribution.

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "$schema": "https://json-schema.org/draft/2020-12/schema",
 "required": [
  "input"
 ],
 "properties": {
  "input": {
   "type": "object",
   "required": [
    "type",
    "method"
   ],
   "properties": {
    "type": {
     "type": "string",
     "const": "http"
    },
    "method": {
     "enum": [
      "GET"
     ],
     "type": "string"
    },
    "queryParams": {
     "type": "object",
     "required": [
      "q"
     ],
     "properties": {
      "q": {
       "type": "string",
       "description": "Gene symbol, name or Ensembl id, e.g. BRCA1, EGFR, ENSG00000146648"
      }
     }
    }
   },
   "additionalProperties": false
  },
  "output": {
   "type": "object",
   "required": [
    "type"
   ],
   "properties": {
    "type": {
     "type": "string",
     "const": "json"
    },
    "example": {
     "type": "object",
     "required": [
      "top_match"
     ],
     "properties": {
      "url": {
       "type": "string",
       "description": "Canonical URL"
      },
      "query": {
       "type": "string",
       "description": "The query as the server interpreted it"
      },
      "source": {
       "type": "string",
       "description": "Data source the values come from"
      },
      "top_match": {
       "type": "object",
       "properties": {
        "name": {
         "type": [
          "string",
          "null"
         ],
         "description": "Name"
        },
        "symbol": {
         "type": [
          "string",
          "null"
         ],
         "description": "Ticker or asset symbol"
        },
        "biotype": {
         "type": [
          "string",
          "null"
         ],
         "description": "Gene biotype such as protein_coding"
        },
        "function": {
         "type": [
          "string",
          "null"
         ],
         "description": "Description of the function"
        },
        "location": {
         "description": "Place the data refers to"
        },
        "ensembl_id": {
         "type": [
          "string",
          "null"
         ],
         "description": "Ensembl id identifier"
        },
        "top_diseases": {
         "type": [
          "array",
          "null"
         ],
         "items": {
          "type": "object",
          "properties": {
           "efo_id": {},
           "disease": {},
           "association_score": {}
          }
         },
         "description": "Top diseases"
        },
        "associated_disease_count": {

… (truncated)
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/saylor-innovations-gene-drug-target-lookup-5c70de03/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from saylorinnovations.com](https://www.zero.xyz/host/saylorinnovations.com/llms.txt)