# Simon Broome Register 1991 Adult Definite Familial Hypercholesterolaemia Classifier

> Simon Broome Register 1991 Adult Definite Familial Hypercholesterolaemia Classifier is a paid API for AI agents from api.magentlab.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-13).

Applies the Simon Broome Register 1991 adult definite FH criteria: checks whether a single lipid value (total cholesterol >7.5 mmol/L or LDL >4.9 mmol/L) plus tendon xanthomas in the patient or a qualifying relative are both met.

## Facts

- Endpoint: GET https://api.magentlab.com/api/calc/simon_broome
- Price: $0.005/call
- Payment: x402
- Status: unknown
- Last checked: 2026-09-13
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/simon-broome-register-1991-adult-definite-familial-605016a8
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_GRh9ly6hiIzkUHokKEKdQ

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability simon-broome-register-1991-adult-definite-familial-605016a8
```

Example prompt: My patient is an adult with a total cholesterol of 8.1 mmol/L and their sibling has tendon xanthomas — do they meet the Simon Broome 1991 adult definite familial hypercholesterolaemia criteria?

## When to prefer this

Use this endpoint when you need to programmatically apply the Simon Broome Register 1991 adult definite FH criteria specifically — i.e., the two-component rule of a qualifying lipid value plus tendon xanthomas in patient or first/second-degree relative. Do not use it for possible FH classification, paediatric FH cutoffs, Dutch Lipid Clinic Network scoring, or DNA-based FH criteria.

## Known failure modes

- More than one lipid parameter supplied — exactly one must be provided
- Lipid value outside accepted range (e.g. LDL mmol/L outside 1–15) — input rejected
- Missing required tendon_xanthoma_patient_or_relative parameter — request fails
- Lipid value exactly at threshold (e.g. 7.5 mmol/L total cholesterol) — threshold is NOT met (strict >)
- Payment not attached (x402) — 402 Payment Required response

## How this service works

Simon Broome Register 1991 adult definite familial hypercholesterolaemia: total cholesterol >7.5 mmol/L or LDL cholesterol >4.9 mmol/L plus tendon xanthomas in the patient or a relative (parent, child, grandparent, sibling, uncle, or aunt). One lipid (mmol/L or mg/dL). magent does not assay lipids or examine tendons. Not a diagnosis, not possible FH, and not a DNA or child-cutoff classifier.

## Output

Returns a structured result indicating whether the patient meets the Simon Broome 1991 adult definite FH criteria, including whether the lipid threshold (total cholesterol >7.5 mmol/L or LDL >4.9 mmol/L) is met and whether the tendon xanthoma criterion is satisfied. Does not provide a diagnosis, does not classify possible FH, and does not apply DNA or paediatric cutoffs.

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "$schema": "https://json-schema.org/draft/2020-12/schema",
 "required": [
  "input"
 ],
 "properties": {
  "input": {
   "type": "object",
   "required": [
    "type",
    "method"
   ],
   "properties": {
    "type": {
     "type": "string",
     "const": "http"
    },
    "method": {
     "enum": [
      "GET",
      "HEAD",
      "DELETE"
     ],
     "type": "string"
    },
    "headers": {
     "type": "object",
     "additionalProperties": {
      "type": "string"
     }
    },
    "queryParams": {
     "type": "object",
     "required": [
      "tendon_xanthoma_patient_or_relative"
     ],
     "properties": {
      "ldl_mg_dl": {
       "type": "number",
       "description": "LDL cholesterol in mg/dL (40-600). Converted to mmol/L as mg/dL / 38.67, then compared with >4.9. Provide exactly one lipid parameter."
      },
      "ldl_mmol_l": {
       "type": "number",
       "description": "LDL cholesterol in mmol/L (1-15). Adult threshold is >4.9 mmol/L (4.9 does not meet). Provide exactly one lipid parameter. magent does not assay lipids."
      },
      "total_cholesterol_mg_dl": {
       "type": "number",
       "description": "Total cholesterol in mg/dL (50-800). Converted to mmol/L as mg/dL / 38.67, then compared with >7.5. Provide exactly one lipid parameter."
      },
      "total_cholesterol_mmol_l": {
       "type": "number",
       "description": "Total cholesterol in mmol/L (1.3-20). Adult threshold is >7.5 mmol/L (7.5 does not meet). Provide exactly one of total_cholesterol_mmol_l, total_cholesterol_mg_dl, ldl_mmol_l, or ldl_mg_dl. magent does not assay lipids."
      },
      "tendon_xanthoma_patient_or_relative": {
       "type": "boolean",
       "description": "Tendon xanthomas in the patient or a relative (parent, child, grandparent, sibling, uncle, or aunt) as assigned by the caller. true or false. magent does not examine tendons or take a pedigree."
      }
     }
    }
   },
   "additionalProperties": false
  },
  "output": {
   "type": "object",
   "required": [
    "type"
   ],
   "properties": {
    "type": {
     "type": "string"
    },
    "example": {
     "type": "object"
    }
   }
  }
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/simon-broome-register-1991-adult-definite-familial-605016a8/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from api.magentlab.com](https://www.zero.xyz/host/api.magentlab.com/llms.txt)