# SiteCheck Health & Travel – GWAS Catalog Associations by Gene

> SiteCheck Health & Travel – GWAS Catalog Associations by Gene is a paid API for AI agents from api.healthtravel-api.workers.dev, paid per call via x402, $0.002/call, status unknown (last checked 2026-10-29).

Returns genome-wide association study (GWAS) hits from the EMBL-EBI GWAS Catalog for a given gene symbol, including trait, SNP, p-value, odds ratio, and study metadata.

## Facts

- Endpoint: GET https://api.healthtravel-api.workers.dev/api/health/gwas-catalog-associations?utm_source=zero.xyz
- Price: $0.002/call
- Payment: x402
- Status: unknown
- Last checked: 2026-10-29
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/sitecheck-health-travel-gwas-catalog-associations-by-gene-0e77128f
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_55UfEa8qKIw2z1JqcCIuK

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability sitecheck-health-travel-gwas-catalog-associations-by-gene-0e77128f
```

Example prompt: Pull up to 8 GWAS Catalog association hits for the gene APOE — I want to see the reported traits, SNPs, p-values, and PubMed IDs for each one.

## When to prefer this

Use this endpoint when you need structured GWAS hit data (SNPs, traits, p-values, odds ratios, study references) for a specific gene symbol from the authoritative EMBL-EBI GWAS Catalog. Prefer it over general genomics databases when you specifically need mapped-gene GWAS associations with EFO trait ontology and study provenance (PubMed/accession). Not suitable for variant-level clinical significance (use ClinVar for that) or for querying by disease/trait rather than gene.

## Known failure modes

- Invalid or unrecognized gene symbol returns no results or an error
- Gene symbol with no GWAS Catalog associations returns an empty result set
- max parameter outside 1–10 range may be rejected or clamped
- EMBL-EBI API downtime causes upstream fetch failure
- Gene symbol too short (<2 chars) or too long (>20 chars) rejected by schema validation

## How this service works

EMBL-EBI GWAS Catalog genome-wide association hits for a gene symbol (REST API v2): reported trait, EFO trait, SNP and locus, p-value, odds ratio or beta, study accession and PubMed ID. Searches by mapped gene only. Up to 10 hits per call.

## Output

Returns up to 10 GWAS association records for the queried gene symbol. Each record includes the reported trait name, EFO ontology trait, SNP identifier and locus, p-value, odds ratio or beta coefficient, GWAS study accession number, and PubMed ID of the source publication.

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "$schema": "https://json-schema.org/draft/2020-12/schema",
 "required": [
  "input"
 ],
 "properties": {
  "input": {
   "type": "object",
   "required": [
    "type",
    "method"
   ],
   "properties": {
    "type": {
     "type": "string",
     "const": "http"
    },
    "method": {
     "enum": [
      "GET"
     ],
     "type": "string"
    },
    "queryParams": {
     "type": "object",
     "required": [
      "gene"
     ],
     "properties": {
      "max": {
       "type": "string",
       "description": "How many associations, 1 to 10 (default 5)"
      },
      "gene": {
       "type": "string",
       "description": "Gene symbol, letters, digits and hyphens, 2 to 20 characters"
      }
     }
    }
   },
   "additionalProperties": false
  },
  "output": {
   "type": "object",
   "required": [
    "type"
   ],
   "properties": {
    "type": {
     "type": "string"
    },
    "example": {
     "type": "object"
    }
   }
  }
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/sitecheck-health-travel-gwas-catalog-associations-by-gene-0e77128f/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from api.healthtravel-api.workers.dev](https://www.zero.xyz/host/api.healthtravel-api.workers.dev/llms.txt)