# SiteCheck Health & Travel – Reactome Biological Pathways

> SiteCheck Health & Travel – Reactome Biological Pathways is a paid API for AI agents from api.healthtravel-api.workers.dev, paid per call via x402, $0.002/call, status unknown (last checked 2026-10-29).

Returns Reactome-curated human biological pathways matching a search term, including stable ID, pathway name, disease flag, and short summary (up to 20 results).

## Facts

- Endpoint: GET https://api.healthtravel-api.workers.dev/api/health/reactome-biological-paths?utm_source=zero.xyz
- Price: $0.002/call
- Payment: x402
- Status: unknown
- Last checked: 2026-10-29
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/sitecheck-health-travel-reactome-biological-pathways-ed11c14b
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_7_I8pzhrtT3m3xK729kz3

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability sitecheck-health-travel-reactome-biological-pathways-ed11c14b
```

Example prompt: Search Reactome for human biological pathways related to 'insulin signaling' and give me up to 10 results, including whether any are disease pathways.

## When to prefer this

Choose this endpoint when you need curated, authoritative human biological pathway data from Reactome with disease annotations, particularly for bioinformatics workflows, gene function research, or drug target discovery. It is ideal when you need pathway stable IDs and summaries for up to 20 pathways per query at very low cost. Prefer it over general web search when structured, machine-readable Reactome pathway data is required.

## Known failure modes

- Query string shorter than 2 or longer than 60 characters returns a validation error
- No pathways found for an obscure or misspelled term returns an empty result set
- Max parameter outside 1–20 range may be rejected or clamped
- Non-human pathway terms may return zero results since only human pathways are included
- Reactome ContentService upstream unavailability causes a 5xx error

## How this service works

Reactome curated human biological pathways matching a term (Reactome ContentService, CC BY 4.0): stable ID, pathway name, whether it is a disease pathway and a short summary. Human pathways only. Up to 20 per call.

## Output

A list of up to 20 Reactome-curated human biological pathways matching the search term. Each result includes the stable pathway ID (e.g. R-HSA-XXXXXX), the pathway name, a boolean or flag indicating whether it is a disease pathway, and a short descriptive summary of the pathway.

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "$schema": "https://json-schema.org/draft/2020-12/schema",
 "required": [
  "input"
 ],
 "properties": {
  "input": {
   "type": "object",
   "required": [
    "type",
    "method"
   ],
   "properties": {
    "type": {
     "type": "string",
     "const": "http"
    },
    "method": {
     "enum": [
      "GET"
     ],
     "type": "string"
    },
    "queryParams": {
     "type": "object",
     "required": [
      "q"
     ],
     "properties": {
      "q": {
       "type": "string",
       "description": "Search words, letters, digits and spaces, 2 to 60 characters"
      },
      "max": {
       "type": "string",
       "description": "How many pathways, 1 to 20 (default 5)"
      }
     }
    }
   },
   "additionalProperties": false
  },
  "output": {
   "type": "object",
   "required": [
    "type"
   ],
   "properties": {
    "type": {
     "type": "string"
    },
    "example": {
     "type": "object"
    }
   }
  }
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/sitecheck-health-travel-reactome-biological-pathways-ed11c14b/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from api.healthtravel-api.workers.dev](https://www.zero.xyz/host/api.healthtravel-api.workers.dev/llms.txt)