# SiteCheck Health & Travel – UniProt Protein Knowledge

> SiteCheck Health & Travel – UniProt Protein Knowledge is a paid API for AI agents from api.healthtravel-api.workers.dev, paid per call via x402, $0.002/call, status unknown (last checked 2026-10-29).

Looks up protein function, organism, and accession data for a human gene symbol from the UniProt knowledgebase

## Facts

- Endpoint: GET https://api.healthtravel-api.workers.dev/api/health/uniprot-protein-knowledge?utm_source=zero.xyz
- Price: $0.002/call
- Payment: x402
- Status: unknown
- Last checked: 2026-10-29
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/sitecheck-health-travel-uniprot-protein-knowledge-bffe1f75
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_oeVXlAJgkz2kZr-fuTZ6t

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability sitecheck-health-travel-uniprot-protein-knowledge-bffe1f75
```

Example prompt: Can you look up the UniProt protein knowledge entry for the TP53 gene — I want to know its protein name, function summary, and accession number?

## When to prefer this

Choose this endpoint when you need structured protein annotation data (function, accession, organism, length) for a specific human gene symbol, sourced directly from UniProt's authoritative knowledgebase, without needing a signup or API key. Prefer it over raw UniProt API calls when you want a pay-per-use, zero-setup integration with normalized JSON output. Not suitable for non-human organisms or bulk proteome queries.

## Known failure modes

- Gene symbol not found in UniProt — returns empty entries array
- Invalid gene symbol format (too short, too long, or illegal characters) — returns validation error
- max parameter out of range (must be 1–5) — returns error
- UniProt upstream service unavailable — returns 5xx or timeout
- Payment failure — call is not charged and returns 402

## How this service works

UniProt reviewed (Swiss-Prot) human protein entries for a gene symbol: accession, protein name, gene, sequence length and the curated function summary. Human only (taxon 9606). Up to 5 entries per call.

## Output

Returns a JSON object containing the queried gene symbol, the UniProt source URL, and an array of entries. Each entry includes the UniProt URL, gene symbol, amino acid sequence length, a function description (with PubMed citations), organism (e.g. Homo sapiens), UniProt accession ID, and protein name. Also includes a checkedAt timestamp.

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "$schema": "https://json-schema.org/draft/2020-12/schema",
 "required": [
  "input"
 ],
 "properties": {
  "input": {
   "type": "object",
   "required": [
    "type",
    "method"
   ],
   "properties": {
    "type": {
     "type": "string",
     "const": "http"
    },
    "method": {
     "enum": [
      "GET"
     ],
     "type": "string"
    },
    "queryParams": {
     "type": "object",
     "required": [
      "gene"
     ],
     "properties": {
      "max": {
       "type": "string",
       "description": "How many entries, 1 to 5 (default 1)"
      },
      "gene": {
       "type": "string",
       "description": "Human gene symbol, letters, digits and hyphens, 2 to 20 characters"
      }
     }
    }
   },
   "additionalProperties": false
  },
  "output": {
   "type": "object",
   "required": [
    "type"
   ],
   "properties": {
    "type": {
     "type": "string"
    },
    "example": {
     "type": "object"
    }
   }
  }
 }
}
```

## Response schema (JSON Schema)

```json
{
 "type": "json",
 "example": {
  "gene": "TP53",
  "source": "https://www.uniprot.org/ (CC BY 4.0)",
  "entries": [
   {
    "url": "https://www.uniprot.org/uniprotkb/P04637",
    "gene": "TP53",
    "length": 393,
    "function": "Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:209594…",
    "organism": "Homo sapiens",
    "accession": "P04637",
    "proteinName": "Cellular tumor antigen p53"
   }
  ],
  "checkedAt": "2026-10-23T09:36:29.124Z"
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/sitecheck-health-travel-uniprot-protein-knowledge-bffe1f75/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from api.healthtravel-api.workers.dev](https://www.zero.xyz/host/api.healthtravel-api.workers.dev/llms.txt)