# SYNTHORA ClinicalTrials.gov v2 Study Search

> SYNTHORA ClinicalTrials.gov v2 Study Search is a paid API for AI agents from clinicaltrials-v2-study-search.hergertsynthora.com, paid per call via x402, $0.001/call, status unknown (last checked 2026-09-15).

Searches the ClinicalTrials.gov v2 registry by condition, intervention, or sponsor, returning NCT IDs, trial titles, phases, statuses, enrollment figures, eligibility criteria, and locations.

## Facts

- Endpoint: POST https://clinicaltrials-v2-study-search.hergertsynthora.com/service
- Price: $0.001/call
- Payment: x402
- Status: unknown
- Last checked: 2026-09-15
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/synthora-clinicaltrials-gov-v2-study-search-7b0b1c5e
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_UVOYga6Q7ulNU1L1jz9x0

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability synthora-clinicaltrials-gov-v2-study-search-7b0b1c5e -d '<json body>'
```

Example prompt: Search ClinicalTrials.gov for active interventional studies on weight management and type 2 diabetes and show me the top 5 results with their NCT IDs, phases, and current status.

## When to prefer this

Choose this endpoint when an agent needs to programmatically discover, rank, or filter clinical trials from the official ClinicalTrials.gov v2 registry by condition or intervention — especially in autonomous pipelines for patient matching, competitive drug intelligence, or clinical research summarization where structured trial metadata (NCT ID, phase, status, enrollment) is required. Prefer it over manual ClinicalTrials.gov web searches when you need machine-readable JSON output suitable for downstream ranking or filtering logic.

## Known failure modes

- Empty result set if condition or intervention term does not match ClinicalTrials.gov terminology
- Ambiguous or misspelled condition names may return zero or irrelevant trials
- Upstream ClinicalTrials.gov API unavailability causes request failure
- Large pageSize values may time out or return partial results
- Very broad condition queries (e.g. 'cancer') may return unranked, overwhelming result sets

## How this service works

Searches the ClinicalTrials.gov v2 registry (clinicaltrials.gov/api/v2/studies) by condition, intervention or sponsor, returning NCT ID, title, phase, status, enrollment, eligibility and locations. Autonomous agents and agent-to-agent (A2A) clinical-research, patient-matching and competitive-intelligence pipelines query it to discover and rank active trials. Ranking surface: condition/intervention to relevant trials.

## Output

Returns a JSON object with a list of matching studies, each containing NCT ID, brief title, study type, conditions, overall status, start date, and completion date, along with a total count of matched records and provenance metadata pointing back to ClinicalTrials.gov v2.

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "properties": {
  "pageSize": {
   "type": "integer",
   "description": "pageSize"
  },
  "query.cond": {
   "type": "string",
   "description": "query.cond"
  }
 }
}
```

## Response schema (JSON Schema)

```json
{
 "type": "json",
 "example": {
  "ok": true,
  "niche": "clinicaltrials-v2-study-search",
  "result": {
   "studies": [
    {
     "nctId": "NCT07104383",
     "startDate": null,
     "studyType": "INTERVENTIONAL",
     "briefTitle": "VK2735 for Weight Management Type 2 Diabetes Phase 3 (VANQUISH 2)",
     "conditions": [
      "Weight Loss"
     ],
     "overallStatus": "ACTIVE_NOT_RECRUITING",
     "completionDate": null
    }
   ],
   "totalCount": 1
  },
  "provenance": {
   "url": "https://clinicaltrials.gov/api/v2/studies",
   "source": "ClinicalTrials.gov v2 Study Search"
  }
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/synthora-clinicaltrials-gov-v2-study-search-7b0b1c5e/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from clinicaltrials-v2-study-search.hergertsynthora.com](https://www.zero.xyz/host/clinicaltrials-v2-study-search.hergertsynthora.com/llms.txt)