# SYNTHORA openFDA NDC Drug Directory Lookup

> SYNTHORA openFDA NDC Drug Directory Lookup is a paid API for AI agents from openfda-drug-ndc-directory.hergertsynthora.com, paid per call via x402, $0.001/call, status unknown (last checked 2026-09-15).

Looks up FDA National Drug Code (NDC) directory records via openFDA, returning product NDC, generic/brand names, dosage form, route, active ingredients, marketing category, and DEA schedule.

## Facts

- Endpoint: POST https://openfda-drug-ndc-directory.hergertsynthora.com/service
- Price: $0.001/call
- Payment: x402
- Status: unknown
- Last checked: 2026-09-15
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/synthora-openfda-ndc-drug-directory-lookup-d33a337c
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_bpbqPutUzohEli1-rz8z1

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability synthora-openfda-ndc-drug-directory-lookup-d33a337c -d '<json body>'
```

Example prompt: Look up the FDA NDC directory record for 'Norgestimate and ethinyl estradiol' — I need the product NDC, dosage form, route, and active ingredients from the openFDA NDC database, limit results to 5.

## When to prefer this

Choose this endpoint when you need to resolve, validate, or enrich a drug product identifier against the authoritative FDA NDC directory, especially in pharmacy, formulary, or pharmaceutical supply-chain workflows where canonical FDA product records are required. Prefer this over generic drug databases when regulatory-grade data (DEA schedule, marketing category, labeler) is needed and when operating in agent-to-agent pipelines that require structured, machine-readable NDC records.

## Known failure modes

- No matching NDC or drug name found — returns total:0 with empty results array
- Invalid search query syntax — openFDA query parse error propagated in response
- Rate limit or upstream openFDA API unavailability — service may return error or timeout
- Limit parameter out of range — may return default or error
- Drug exists but has no route or active ingredients populated in FDA records — returns null fields

## How this service works

Returns FDA National Drug Code (NDC) directory records from openFDA api.fda.gov/drug/ndc: product_ndc, generic_name, brand_name, dosage_form, route, active ingredients, marketing category and DEA schedule. Lets autonomous agents and agent-to-agent (A2A) pipelines resolve, validate and enrich drug product identifiers during pharmacy, formulary and supply-chain workflows. Ranking surface: match NDC to canonical FDA product record.

## Output

Returns a JSON object with ok status, total match count, and an array of NDC directory records each containing product_ndc, generic_name, brand_name, dosage_form, route, labeler_name, active_ingredients array, marketing_start_date, and finished product flag; provenance metadata includes the source openFDA URL.

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "properties": {
  "limit": {
   "type": "integer",
   "description": "limit"
  },
  "search": {
   "type": "string",
   "description": "search"
  }
 }
}
```

## Response schema (JSON Schema)

```json
{
 "type": "json",
 "example": {
  "ok": true,
  "niche": "openfda-drug-ndc-directory",
  "result": {
   "total": 1,
   "results": [
    {
     "route": null,
     "finished": true,
     "brand_name": "Norgestimate and ethinyl estradiol",
     "dosage_form": "KIT",
     "product_ndc": "79929-008",
     "generic_name": "Norgestimate and ethinyl estradiol",
     "labeler_name": "Naari Pte Limited",
     "active_ingredients": [],
     "marketing_start_date": "20240331"
    }
   ]
  },
  "provenance": {
   "url": "https://api.fda.gov/drug/ndc.json",
   "source": "openFDA NDC Drug Directory Lookup"
  }
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/synthora-openfda-ndc-drug-directory-lookup-d33a337c/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from openfda-drug-ndc-directory.hergertsynthora.com](https://www.zero.xyz/host/openfda-drug-ndc-directory.hergertsynthora.com/llms.txt)