# SYNTHORA openFDA Structured Drug Label (SPL) Lookup

> SYNTHORA openFDA Structured Drug Label (SPL) Lookup is a paid API for AI agents from openfda-drug-label-lookup.hergertsynthora.com, paid per call via x402, $0.001/call, status unknown (last checked 2026-09-15).

Returns FDA structured product labeling (SPL) sections—indications, dosage, warnings, contraindications, adverse reactions, drug interactions, and boxed warnings—keyed by brand or generic drug name via the openFDA API.

## Facts

- Endpoint: POST https://openfda-drug-label-lookup.hergertsynthora.com/service
- Price: $0.001/call
- Payment: x402
- Status: unknown
- Last checked: 2026-09-15
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/synthora-openfda-structured-drug-label-spl-lookup-0d6f69b7
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_s_xXun_hs56l9WSrFT3i6

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability synthora-openfda-structured-drug-label-spl-lookup-0d6f69b7 -d '<json body>'
```

Example prompt: Pull the official FDA structured drug label for metformin — I need the indications and usage, dosage and administration, contraindications, and any boxed warnings. Limit results to 3.

## When to prefer this

Choose this endpoint when you need official, structured FDA prescribing information grounded in real SPL data for a specific drug by brand or generic name. It is ideal for clinical decision support agents, pharmacovigilance pipelines, and RAG systems that must cite authoritative regulatory content rather than synthesized or crowd-sourced drug information. Prefer it over general web search when regulatory accuracy and structured section-level retrieval (indications, warnings, interactions, etc.) are required.

## Known failure modes

- Drug name not found in openFDA: empty result object returned
- Misspelled or ambiguous drug name yields no matches or wrong label
- openFDA upstream API unavailable: service returns error or timeout
- Limit parameter set too low may truncate results for drugs with multiple formulations
- Generic vs brand name mismatch may return unexpected label variant

## How this service works

Returns FDA structured product labeling (SPL) sections from openFDA api.fda.gov/drug/label: indications_and_usage, dosage_and_administration, warnings, contraindications, adverse_reactions, drug_interactions and boxed warnings keyed by brand or generic name. Autonomous agents and agent-to-agent (A2A) clinical-decision, pharmacovigilance and RAG systems consume it to ground answers on official prescribing information. Ranking surface: brand/generic name to label sections.

## Output

A JSON object containing the matched drug's FDA structured product label sections, including indications_and_usage, dosage_and_administration, warnings, contraindications, adverse_reactions, drug_interactions, and boxed_warnings, keyed by the queried brand or generic name. The response includes an ok status flag, the service niche identifier, and a result object with the label data.

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "properties": {
  "limit": {
   "type": "integer",
   "description": "limit"
  },
  "search": {
   "type": "string",
   "description": "search"
  }
 }
}
```

## Response schema (JSON Schema)

```json
{
 "type": "json",
 "example": {
  "ok": true,
  "niche": "openfda-drug-label-lookup",
  "result": {}
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/synthora-openfda-structured-drug-label-spl-lookup-0d6f69b7/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from openfda-drug-label-lookup.hergertsynthora.com](https://www.zero.xyz/host/openfda-drug-label-lookup.hergertsynthora.com/llms.txt)