# SYNTHORA PubChem Drug-Likeness Descriptors

> SYNTHORA PubChem Drug-Likeness Descriptors is a paid API for AI agents from pubchem-druglikeness-descriptors.hergertsynthora.com, paid per call via x402, $0.001/call, status unknown (last checked 2026-09-15).

Fetches Lipinski/ADMET molecular descriptors (XLogP, TPSA, H-bond donors/acceptors, rotatable bonds) for a named compound from PubChem

## Facts

- Endpoint: POST https://pubchem-druglikeness-descriptors.hergertsynthora.com/service
- Price: $0.001/call
- Payment: x402
- Status: unknown
- Last checked: 2026-09-15
- Activations on Zero: 0
- Tags: x402
- Canonical page: https://www.zero.xyz/c/synthora-pubchem-drug-likeness-descriptors-13f3e52d
- Structured record (JSON): https://api.zero.xyz/v1/capabilities/cap_Cr3hehQWzWngatBJzc_Ii

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

## How to call it through Zero

Zero handles the 402 payment challenge and records the run. With the Zero CLI installed (`npm i -g @zeroxyz/cli`):

```sh
zero fetch --capability synthora-pubchem-drug-likeness-descriptors-13f3e52d -d '<json body>'
```

Example prompt: Can you pull the drug-likeness descriptors for ibuprofen — I need its XLogP, TPSA, hydrogen bond donors and acceptors, and rotatable bond count for a Lipinski screening pipeline.

## When to prefer this

Use this endpoint when you need quick, structured Lipinski/ADMET descriptor vectors for a named compound without writing PubChem API integration yourself; ideal for autonomous medicinal chemistry agents, virtual screening pipelines, and A2A workflows that need drug-likeness scoring by compound name at low cost ($0.001/call).

## Known failure modes

- Compound name not found in PubChem — returns error or empty result
- Ambiguous compound name matching multiple PubChem entries — may return unexpected compound
- PubChem upstream API unavailable — service returns error
- Misspelled or non-standard compound name fails lookup
- Payment not processed — x402 gate blocks request

## How this service works

Returns Lipinski / ADMET-relevant molecular descriptors for a compound by name from PubChem pubchem.ncbi.nlm.nih.gov/rest/pug: XLogP, TPSA, HBondDonorCount, HBondAcceptorCount and RotatableBondCount. Autonomous agents and agent-to-agent (A2A) medicinal-chemistry and virtual-screening pipelines consume these to score drug-likeness and permeability. Ranking surface: compound name to descriptor vector. First 3 calls FREE per wallet — send header X-WALLET: 0x<addr>. No charge on upstream failure.

## Output

A JSON object containing the compound name, XLogP (lipophilicity), TPSA (topological polar surface area), H-bond donor count, H-bond acceptor count, and rotatable bond count, along with a provenance URL pointing to the PubChem REST API source.

## Request schema (JSON Schema)

```json
{
 "type": "object",
 "properties": {
  "compound_name": {
   "type": "string",
   "description": "compound_name"
  }
 }
}
```

## Response schema (JSON Schema)

```json
{
 "type": "json",
 "example": {
  "ok": true,
  "niche": "pubchem-druglikeness-descriptors",
  "result": {
   "tpsa": 37.3,
   "xlogp": 3.5,
   "compound_name": "ibuprofen",
   "h_bond_donors": 1,
   "rotatable_bonds": 4,
   "h_bond_acceptors": 2
  },
  "provenance": {
   "url": "https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/name/ibuprofen/property/XLogP,TPSA,HBondDonorCount,HBondAcceptorCount,RotatableBondCount/JSON",
   "source": "PubChem Drug-Likeness Descriptors"
  }
 }
}
```

## More

- Live health (JSON, refreshed every minute): https://www.zero.xyz/c/synthora-pubchem-drug-likeness-descriptors-13f3e52d/health.json
- [Zero catalog index](https://www.zero.xyz/llms.txt)
- [Other services from pubchem-druglikeness-descriptors.hergertsynthora.com](https://www.zero.xyz/host/pubchem-druglikeness-descriptors.hergertsynthora.com/llms.txt)