# Services from bio.halowerk.com on Zero

> bio.halowerk.com serves 10 paid API services for AI agents, indexed by Zero. Each is callable per call with payment handled by Zero.

Canonical page: https://www.zero.xyz/host/bio.halowerk.com
Live health (JSON, refreshed every minute): https://www.zero.xyz/host/bio.halowerk.com/health.json

## Services

- [CRISPR Off-Target Similarity Scorer](https://www.zero.xyz/c/crispr-off-target-similarity-scorer-ad357447/llms.txt): $0.004/call via x402. Ranks user-supplied candidate protospacers against a guide RNA sequence using a mismatch-weighted similarity score with NGG PAM penalty, emphasizing the guide's seed region (final 10 positions).
- [Biomarker Longevity Index Calculator](https://www.zero.xyz/c/biomarker-longevity-index-calculator-72d9ac7a/llms.txt): $0.003/call via x402. Standardizes caller-supplied biomarker values against provided reference means and standard deviations, flips markers where lower is better, and computes a weighted composite score mapped to a 0–100 index.
- [Microbiome Diversity Calculator](https://www.zero.xyz/c/microbiome-diversity-calculator-b1c4adc3/llms.txt): $0.003/call via x402. Normalizes taxon counts and computes observed richness, Shannon entropy, Simpson diversity, and Pielou evenness from caller-supplied species count data
- [HP Lattice Protein Folding Energy Evaluator](https://www.zero.xyz/c/hp-lattice-protein-folding-energy-evaluator-df008488/llms.txt): $0.004/call via x402. Validates a 2D hydrophobic/polar (HP) lattice conformation and computes its energy by counting non-consecutive hydrophobic contacts, assigning -1 energy unit per contact.
- [Phage Sequence Spacer Hamming Distance Matcher](https://www.zero.xyz/c/phage-sequence-spacer-hamming-distance-matcher-bc6f2b78/llms.txt): $0.004/call via x402. Slides each caller-supplied CRISPR spacer over a phage sequence in both orientations and reports minimum Hamming distances within a caller-selected mismatch threshold
- [bio.halowerk.com Allergen Epitope Similarity Analyzer](https://www.zero.xyz/c/bio-halowerk-com-allergen-epitope-similarity-analyzer-8ee11ef9/llms.txt): $0.004/call via x402. Builds amino-acid k-mer sets from a query protein sequence and known epitopes, computes Jaccard similarity, and finds the highest contiguous identity window between each epitope and the query sequence.
- [DNA Storage Encoder (2-bit UTF-8 to Nucleotide)](https://www.zero.xyz/c/dna-storage-encoder-2-bit-utf-8-to-nucleotide-8d4eff9a/llms.txt): $0.003/call via x402. Encodes UTF-8 text into a DNA nucleotide string by mapping each two-bit group to A, C, G, or T, and returns a SHA-256 checksum of the original bytes.
- [Tissue Scaffold Fluid Permeability Calculator](https://www.zero.xyz/c/tissue-scaffold-fluid-permeability-calculator-40f6e735/llms.txt): $0.003/call via x402. Computes fluid permeability and flow rate through a porous tissue scaffold using the Kozeny-Carman relation and Darcy's law given porosity, pore diameter, thickness, viscosity, and pressure drop.
- [Halowerk Basic Reproduction Number (R0) Calculator](https://www.zero.xyz/c/halowerk-basic-reproduction-number-r0-calculator-5484f784/llms.txt): $0.003/call via x402. Computes a basic reproduction number (R0) and effective reproduction number (Re) using a simple homogeneous-mixing formula from transmission probability, contact rate, and infectious duration.
- [Synthetic Yeast Yield Calculator](https://www.zero.xyz/c/synthetic-yeast-yield-calculator-94c085be/llms.txt): $0.003/call via x402. Computes theoretical maximum product yield from multiple substrates by identifying the limiting substrate and applying a process efficiency factor.

Status and success rate cover calls made through Zero and Zero's own probes. Third-party monitors may report differently.

- [Zero catalog index](https://www.zero.xyz/llms.txt)