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Bicarbonate Deficit Calculator (Adrogué–Madias)
x402
Bicarbonate Deficit Calculator (Adrogué–Madias) is a paid API for AI agents from api.magentlab.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-15).
Calculates the bicarbonate deficit from patient weight and measured plasma HCO3 using the Adrogué–Madias 50% body-weight space formula.
Price / call$0.005
Success—
StatusUnknown
How this service works
Bicarbonate deficit from weight and measured HCO3 using Adrogué–Madias 50 percent body-weight space. Deterministic published arithmetic with citation; not a dosing protocol.
Output
Returns the calculated bicarbonate deficit in mmol based on the Adrogué–Madias formula (deficit = 0.5 × weight_kg × (desired_HCO3 − measured_HCO3)), along with the formula citation and input echo. This is a deterministic arithmetic result, not a clinical dosing protocol.
Example use cases
ICU metabolic acidosis correction
“My ICU patient weighs 85 kg and has a plasma bicarbonate of 10 mmol/L. Using the Adrogué–Madias 50% body-weight formula, what is their bicarbonate deficit if we're targeting 24 mmol/L?”
ED bicarb deficit for DKA workup
“I have a 60 kg patient in the ED with a measured HCO3 of 8 mmol/L. Can you calculate the bicarbonate deficit using the standard formula, targeting a bicarb of 18 mmol/L?”
Nephrology consult bicarb space estimation
“Patient is 155 lbs with a plasma bicarbonate of 16 mmol/L and we want to target 24 mmol/L. What does the Adrogué–Madias formula give for bicarbonate deficit?”
Technical details
Endpoint
GEThttps://api.magentlab.com/api/calc/bicarbonate_deficitWhen to prefer
Choose this endpoint when you need a fast, deterministic, citation-backed bicarbonate deficit calculation using the Adrogué–Madias 50% body-weight distribution model. It is ideal for clinical decision-support agents, medical education tools, or audit workflows where reproducibility and published formula provenance matter. It is not a dosing protocol and should not replace clinical judgment.
Side effects
- Missing required bicarbonate_mmol_l parameter returns a 400 error
- bicarbonate_mmol_l outside the valid range of 2–45 mmol/L returns a validation error
- desired_hco3_mmol_l must exceed measured HCO3 or the calculation is invalid
- desired_hco3_mmol_l outside 8–30 mmol/L range rejected
- Neither weight_kg nor weight_lb provided may result in a missing-weight error
- Payment not attached or insufficient USDC (x402) returns 402 Payment Required
Input
Schema · Request body
| Field | Type | Description |
|---|---|---|
| inputrequired | object | |
| output | object |
Output
Schema · Response
{
"type": "json",
"example": {
"path": "/api/calc/bicarbonate_deficit",
"count": 2,
"items": [
{
"formula": "adrogue_madias",
"citation": {
"id": "adrogue-madias-1998",
"doi": "10.1056/NEJM199801013380106",
"title": "Management of life-threatening acid-base disorders. First of two parts",
"source": "N Engl J Med. 1998;338(1):26-34",
"authors": "Adrogué HJ, Madias NE"
},
"weight_kg": 70,
"disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
"deficit_meq": 140,
"bicarbonate_mmol_l": 4,
"formula_expression": "bicarbonate_space_L = 0.5 * weight_kg; deficit_mEq = bicarbonate_space_L * (desired_hco3 - measured_hco3)",
"bicarbonate_space_l": 35,
"desired_hco3_mmol_l": 8
},
{
"formula": "adrogue_madias",
"citation": {
"id": "adrogue-madias-1998",
"doi": "10.1056/NEJM199801013380106",
"title": "Management of life-threatening acid-base disorders. First of two parts",
"source": "N Engl J Med. 1998;338(1):26-34",
"authors": "Adrogué HJ, Madias NE"
},
"weight_kg": 70,
"disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
"deficit_meq": 140,
"bicarbonate_mmol_l": 4,
"formula_expression": "bicarbonate_space_L = 0.5 * weight_kg; deficit_mEq = bicarbonate_space_L * (desired_hco3 - measured_hco3)",
"bicarbonate_space_l": 35,
"desired_hco3_mmol_l": 8
}
]
}
}Tags
x402
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