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ChEMBL Affinity Oracle MCP
x402
ChEMBL Affinity Oracle MCP is a paid API for AI agents from api.m2mcent.com, paid per call via x402, $0.3/call, status unknown (last checked 2026-09-14).
Queries and predicts compound-target binding affinity data using the ChEMBL bioactivity database
Price / call$0.3
Success—
StatusUnknown
How this service works
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Output
Returns bioactivity and binding affinity data from ChEMBL, including quantitative measures such as IC50, Ki, EC50, or Kd values for the queried compound-target pair, along with assay metadata and confidence information.
Example use cases
Drug candidate potency screening
“I need to check the IC50 and Ki values for compound CHEMBL1234 against the EGFR receptor — can you pull that bioactivity data from ChEMBL?”
Selectivity profile for a small molecule
“Look up all the known protein targets and their binding affinities for aspirin in the ChEMBL database so I can assess its selectivity profile.”
Lead optimization comparison
“Can you retrieve the EC50 values for both erlotinib and gefitinib against the EGFR kinase so I can compare their potencies for my lead optimization report?”
Technical details
Endpoint
POSThttps://api.m2mcent.com/chembl-affinity-oracle-mcp/api/processWhen to prefer
Choose this endpoint when you need structured, curated bioactivity and binding affinity data sourced from the ChEMBL database for drug discovery or cheminformatics workflows. Prefer it over generic chemistry search APIs when you specifically need quantitative pharmacological activity data (IC50, Ki, EC50) against named protein targets.
Side effects
- Compound or target not found in ChEMBL database returns empty or null results
- Ambiguous query string leads to multiple matched entries requiring disambiguation
- Malformed SMILES or invalid ChEMBL ID returns a parsing error
- Network timeout or service unavailability returns a 402 or 5xx error
- Query too broad returns truncated or paginated results
Input
Schema · Request body
| Field | Type | Description |
|---|---|---|
| payload | string |
Output
Schema · Response
{
"type": "json",
"example": {
"success": true
}
}Tags
x402
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