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CIOMS R Factor Calculator (Bénichou 1990)
x402
CIOMS R Factor Calculator (Bénichou 1990) is a paid API for AI agents from api.magentlab.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-13).
Computes the CIOMS R factor from ALT, ALP, and their laboratory upper limits of normal to classify drug-induced liver injury pattern as hepatocellular, cholestatic, or mixed.
Price / call$0.005
Success—
StatusUnknown
How this service works
CIOMS R factor from ALT, ALP, and laboratory ULNs (Bénichou 1990). R = (ALT/ALT_ULN)/(ALP/ALP_ULN), rounded to 1 decimal, then hepatocellular (R ≥ 5), cholestatic (R ≤ 2), or mixed (2 < R < 5). Deterministic published arithmetic with citation. Not a medical device, not a DILI diagnosis or RUCAM score; magent does not assay enzymes. R is the enzyme pattern only.
Output
Returns the computed R factor value (rounded to one decimal place) and the CIOMS pattern classification: hepatocellular (R ≥ 5), cholestatic (R ≤ 2), or mixed (2 < R < 5), based on the formula R = (ALT/ALT_ULN) / (ALP/ALP_ULN) per Bénichou 1990.
Example use cases
Drug hepatotoxicity pattern classification
“A patient on a new medication has ALT of 250 U/L with a lab ULN of 45 U/L and ALP of 80 U/L with a lab ULN of 110 U/L — calculate the R factor and tell me if this is hepatocellular, cholestatic, or mixed injury.”
Pharmacovigilance case review
“For a suspected drug reaction report, I need the CIOMS R factor: ALT is 320 U/L, ALT ULN is 40 U/L, ALP is 210 U/L, ALP ULN is 130 U/L. What's the R value and the liver injury pattern?”
Clinical trial safety data annotation
“I'm reviewing a safety event — ALT came back at 95 U/L against a ULN of 35 U/L, and ALP is 145 U/L against a ULN of 100 U/L. Compute the Bénichou R factor so I can label the enzyme pattern.”
Technical details
Endpoint
GEThttps://api.magentlab.com/api/calc/r_factorWhen to prefer
Use this endpoint when you need a deterministic, standards-referenced CIOMS R factor calculation using lab-specific ULNs rather than assumed normal ranges. Prefer it when building pharmacovigilance pipelines, annotating DILI cases, or automating hepatotoxicity pattern classification in clinical trial safety workflows. It is not a RUCAM calculator and does not perform diagnosis — it computes the enzyme pattern ratio only.
Side effects
- Missing required query parameters (alt_u_l, alp_u_l, alt_uln_u_l, alp_uln_u_l) returns a 4xx validation error
- ALP or ALP ULN of 0 causes division-by-zero and is rejected (must be >0)
- Values outside accepted ranges (e.g. ALT ULN outside 5–200 U/L) may be rejected with validation error
- Payment not included or insufficient (x402 protocol) results in 402 Payment Required
Input
Schema · Request body
| Field | Type | Description |
|---|---|---|
| inputrequired | object | |
| output | object |
Tags
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