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ClinicalIntelPulse Disease Landscape
x402
ClinicalIntelPulse Disease Landscape is a paid API for AI agents from clinicalintelpulse.vercel.app, paid per call via x402, $0.35/call, status unknown (last checked 2026-09-13).
Returns a complete pipeline intelligence snapshot for any disease area, covering Phase 2-3 trial map, mechanism coverage, approved therapies, PDUFA calendar, competitive gaps, and market dynamics.
Price / call$0.35
Success—
StatusUnknown
How this service works
Competitive drug pipeline landscape for any disease — full Phase 2/3 trial map, mechanism-of-action coverage, approved drugs, PDUFA calendar, M&A activity, opportunity gaps and investment thesis. Worldwide. For biotech and pharma intelligence agents.
Output
A structured report covering: active Phase 2/3 trials in the disease area, mechanism-of-action distribution across the pipeline, approved therapy landscape, upcoming PDUFA/regulatory milestones, identified whitespace and competitive gaps, and key sponsor/competitive dynamics.
Example use cases
Example prompt
“Give me a full pipeline intelligence report for MASH — I want the Phase 2 and 3 trial map, mechanism coverage, approved landscape, any upcoming PDUFA dates, and where the competitive gaps are.”
Technical details
Endpoint
GEThttps://clinicalintelpulse.vercel.app/api/clinical/disease-landscapeWhen to prefer
Use this endpoint when you need a broad, synthesized intelligence snapshot across an entire disease area in one call — rather than querying individual trial details, single-company pipelines, or specific NCT IDs. Ideal for competitive landscape assessments, investment diligence, BD/licensing scans, or strategic planning where you want Phase 2-3 map, approved drugs, PDUFA dates, and competitive gaps all in one response.
Side effects
- Unknown or misspelled disease name returns an error or empty results
- Very rare or newly-named diseases may have sparse pipeline data
- PDUFA calendar may be incomplete if no near-term approvals are pending
- Rate limiting or payment failure on the x402 micropayment layer
- Stale data if underlying registry sources have not been recently refreshed
Input
Schema · Request body
| Field | Type | Description |
|---|---|---|
| inputrequired | object | |
| output | object |
Output
Schema · Response
{
"type": "json",
"example": {
"deal_activity": "Highly active M&A space. AstraZeneca acquired Eccogene NASH program ($185M). Roche/Genentech building liver portfolio. Novo Nordisk GLP-1 dominance creating competitive panic.",
"query_summary": {
"as_of": "2026-06-07",
"depth": "standard",
"condition": "NASH (Nonalcoholic Steatohepatitis)"
},
"approved_drugs": [
{
"name": "Resmetirom (Rezdiffra)",
"sponsor": "Madrigal Pharmaceuticals",
"approved": "2024-03",
"mechanism": "THR-β agonist",
"indication": "NASH with moderate-to-advanced fibrosis"
}
],
"pdufa_calendar": [
{
"drug": "Lanifibranor",
"sponsor": "Inventiva",
"mechanism": "Pan-PPAR",
"pdufa_estimate": "2026-Q1",
"priority_review": false
}
],
"investment_thesis": "NASH market projected $18-25B by 2030. Resmetirom first approval sets pricing precedent. GLP-1 combination therapy is the likely future standard of care.",
"opportunity_score": {
"max": 100,
"note": "Validated market with first approval. GLP-1 expansion threatening narrow competitors.",
"score": 78,
"rating": "High Value"
},
"pipeline_overview": {
"phase2_count": 48,
"phase3_count": 19,
"total_active": 67,
"approved_drugs": 2,
"approval_recent_12m": 1
},
"top_phase3_assets": [
{
"drug": "Semaglutide 2.4mg",
"nctId": "NCT04858633",
"sponsor": "Novo Nordisk",
"mechanism": "GLP-1 RA",
"completion": "2025-Q4",
"significance": "Blockbuster potential — NASH + obesity combined label"
}
],
"mechanism_landscape": {
"crowded": [
"FXR agonists (8 Phase 2/3)",
"ACC inhibitors (6)",
"FGF21 analogs (5)"
],
"emerging": [
"Pan-PPAR agonists",
"GLP-1/GIP combinations (semaglutide expanding)"
],
"opportunity_gaps": [
"Cirrhosis reversal agents",
"Pediatric NAFLD",
"Combination sequential therapy protocols"
]
},
"key_readouts_next_18m": [
"NASH-RESOLVE (semaglutide histology 2025)",
"MAESTRO-NASH (lanifibranor 2025)",
"ATLAS trial (aldafermin 2026)"
]
}
}Tags
x402
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