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CMS NADAC Drug Acquisition Cost Lookup
x402
CMS NADAC Drug Acquisition Cost Lookup is a paid API for AI agents from data.spencermcw.com, paid per call via x402, $0.01/call, status unknown (last checked 2026-10-23).
Returns the CMS National Average Drug Acquisition Cost (NADAC) per unit for a given NDC, including current price, generic equivalent pricing, and weekly price history since January 2025.
Price / call$0.01
Success—
StatusUnknown
How this service works
What do US pharmacies pay for this drug? CMS’s National Average Drug Acquisition Cost (NADAC) per unit for an NDC, the generic’s NADAC for a brand and the weekly price history since January 2025, from CMS’s NADAC files on data.medicaid.gov. Updated weekly. $0.01 per call (x402, USDC on Base); 3 free calls a day.
Output
Returns a JSON object with the drug's NDC, description, pricing unit, OTC status, classification, pharmacy type, whether it is currently listed in the latest weekly CMS file, the current NADAC per unit with effective date and explanation codes, the last-listed price if currently unlisted, the corresponding generic's NADAC (for brand-name drugs), same-description flag, and a full weekly price history array (newest first) showing runs of identical NADAC values with their date ranges and week counts.
Example use cases
Pharmacy drug cost verification
“Look up the current CMS NADAC price per unit for NDC 00378-0093-05 — I need to know what pharmacies are paying for it and whether it's changed recently.”
Brand vs generic acquisition cost comparison
“For NDC 59148-0006-71, what is the NADAC per unit and what does the corresponding generic cost pharmacies under CMS pricing?”
Drug price trend monitoring
“Pull up the weekly NADAC price history since January 2025 for NDC 16714-0687-01 — I want to see if the acquisition cost has been trending up or down.”
Technical details
Endpoint
GEThttps://data.spencermcw.com/v1/drug/nadac?utm_source=zero.xyzWhen to prefer
Choose this endpoint when you need authoritative CMS NADAC pharmacy acquisition costs for a specific NDC, including historical weekly pricing trends since January 2025 and generic equivalent costs. It is ideal for healthcare cost transparency tools, pharmacy benefit analysis, drug pricing dashboards, or any workflow that needs to compare brand vs generic acquisition costs using official CMS data. Prefer this over general drug price databases when you specifically need what US pharmacies pay (acquisition cost), not retail or insurance reimbursement rates.
Side effects
- Invalid NDC format — must be 11 digits or formatted as XXXXX-XXXX-XX; returns error if pattern does not match
- NDC not found in CMS NADAC database — drug may not be covered or may have never appeared in NADAC files
- Rate limit exceeded beyond 3 free daily calls without payment — requires x402 USDC payment on Base
- Payment failure — x402 transaction rejected or insufficient USDC balance
- Data lag — CMS files are updated weekly so very recent pricing changes may not yet be reflected
Input
Schema · Request body
| Field | Type | Description |
|---|---|---|
| inputrequired | object | |
| output | object |
Tags
x402
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