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CNS-IPI Calculator (Schmitz 2016) — DLBCL CNS Relapse Risk
x402
CNS-IPI Calculator (Schmitz 2016) — DLBCL CNS Relapse Risk is a paid API for AI agents from api.magentlab.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-14).
Calculates the CNS-IPI score (0–6) for DLBCL patients to estimate CNS relapse risk after R-CHOP, based on five standard IPI factors plus kidney/adrenal involvement.
Price / call$0.005
Success—
StatusUnknown
How this service works
Schmitz 2016 CNS-IPI: Shipp IPI factors (age >60, ECOG ≥2, LDH > ULN, Ann Arbor III or IV, extranodal sites >1) plus kidney and/or adrenal involvement; 1 point each, max 6. Low 0–1, intermediate 2–3, high 4–6. CNS relapse risk after R-CHOP in DLBCL. Deterministic published score; not a CNS prophylaxis or LP order; not NCCN-IPI; not R-IPI; not a DLBCL diagnosis. magent does not stage lymphoma or image kidneys.
Output
Returns a CNS-IPI total score (integer 0–6), individual factor contributions, and the corresponding risk category (low: 0–1, intermediate: 2–3, high: 4–6), reflecting the Schmitz 2016 published algorithm for CNS relapse risk estimation in DLBCL after R-CHOP.
Example use cases
CNS relapse risk after R-CHOP
“My patient is 72 years old with DLBCL, ECOG performance status 3, LDH elevated above the lab's upper limit, Ann Arbor stage III, only one extranodal site, and no kidney or adrenal involvement. What is their CNS-IPI score and risk group?”
Low-risk CNS-IPI stratification
“I have a younger DLBCL patient, 54 years old, ECOG 1, LDH is normal, stage II, one extranodal site, no kidney or adrenal involvement. Can you run the Schmitz CNS-IPI and tell me if they're low risk for CNS relapse?”
High-risk CNS-IPI with adrenal involvement
“Score this DLBCL patient on the CNS-IPI: age 61, ECOG 2, LDH above normal, stage IV, more than one extranodal site, and adrenal gland involvement confirmed. I want the total score and whether that puts them in the high-risk category.”
Technical details
Endpoint
GEThttps://api.magentlab.com/api/calc/cns_ipiWhen to prefer
Use this endpoint when you need to deterministically compute the Schmitz 2016 CNS-IPI score for a DLBCL patient — specifically when you need the six-factor variant (standard IPI factors plus kidney/adrenal involvement) rather than the original Shipp 1993 IPI, the R-IPI, or the NCCN-IPI. Prefer this over generic clinical calculators when you need a reproducible, published-formula result with no LLM hallucination risk. It is not a substitute for clinical staging, imaging, or LP ordering decisions.
Side effects
- Missing required query parameters (age, ecog, ldh_gt_uln, stage_iii_or_iv, extranodal_gt_1, kidney_or_adrenal) returns a 400 error
- Age outside 18–120 range returns a validation error
- Non-integer values for age or ecog return a schema error
- ECOG value outside 0–4 range may return an error
- Payment failure or missing x402 header results in a 402 Payment Required response
Input
Schema · Request body
| Field | Type | Description |
|---|---|---|
| inputrequired | object | |
| output | object |
Tags
x402
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