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FDA Drug-Drug Interaction Checker
x402
FDA Drug-Drug Interaction Checker is a paid API for AI agents from payanagent.com, paid per call via x402, $0.15/call, status unknown (last checked 2026-09-14).
Checks pairs of medications against FDA label text to identify drug-drug interactions, risk levels, and clinical guidance
Price / call$0.15
Success—
StatusUnknown
How this service works
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Output
Returns a JSON object with pairwise interaction details for every drug pair (risk level: minor/moderate/serious, evidence from FDA label, what could happen, what to do), an overall_risk summary, a bottom_line statement, any class-level warnings (e.g. NSAID class flags), and a disclaimer. Also reports which drugs were found or not found in FDA data.
Example use cases
Pre-prescription safety screen
“I'm about to start taking Eliquis and my doctor also wants me on aspirin — can you check if those two interact and tell me how serious the risk is?”
Polypharmacy review for elderly patient
“Can you check all the interactions between metformin, lisinopril, atorvastatin, and aspirin? I need to know which pairs are risky and what could go wrong.”
Multilingual medication counseling
“Por favor verifica si hay interacciones entre warfarina e ibuprofeno, y explícamelo en español.”
Technical details
Endpoint
GEThttps://payanagent.com/x402/kh71hpj74fjyvcetc4e6cr49m98ac1zmWhen to prefer
Use this endpoint when you need FDA-label-grounded drug interaction information for 2–8 medications, especially when multilingual output is required. Prefer it over general LLM drug knowledge when traceable evidence citations from FDA labels are needed. It is well-suited for agent workflows that automate medication safety checks, patient intake screening, or pharmacy support tools.
Side effects
- Drug name not recognized in FDA database — returned in drugs_not_found with missing_data_note
- Fewer than two or more than eight drug names provided — likely validation error
- Unsupported language code — may default to English or return error
- Payment not received — x402 payment required before response is served
- Network or upstream FDA data unavailability — service may return error
Input
Schema · Request body
| Field | Type | Description |
|---|---|---|
| lang | en | es | fr | de | ja | zh | ko | pt | ar | hi (default: en) | |
| drugs | Two to eight medication names, comma-separated — e.g. "warfarin,ibuprofen" | "Eliquis,aspirin,omeprazole" |
Output
Schema · Response
{
"type": "json",
"example": {
"pairwise": [
{
"pair": [
"warfarin",
"ibuprofen"
],
"risk": "serious",
"evidence": "Warfarin label — Drug Interactions (NSAIDs); Ibuprofen label — Warnings",
"what_to_do": "Ask your doctor or pharmacist before combining these; they may suggest a safer pain reliever such as acetaminophen.",
"what_could_happen": "Taking them together raises the risk of serious bleeding, including stomach and intestinal bleeding."
}
],
"disclaimer": "This is an automated screen of FDA label text, not a substitute for a pharmacist or doctor. Label interaction sections are not exhaustive. Always confirm with your pharmacist before combining medications.",
"bottom_line": "This is a well-known, potentially serious combination — do not take them together without professional guidance.",
"class_flags": [
"Warfarin label warns about NSAIDs as a class — ibuprofen is an NSAID."
],
"overall_risk": "serious",
"query_summary": {
"drugs": [
"warfarin",
"ibuprofen"
],
"drugs_found": [
"warfarin",
"ibuprofen"
],
"drugs_not_found": []
},
"missing_data_note": "All drugs were found in FDA data."
}
}Tags
x402
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