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Greipp 2005 ISS Myeloma Staging Calculator
x402
Greipp 2005 ISS Myeloma Staging Calculator is a paid API for AI agents from api.magentlab.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-15).
Computes the International Staging System (ISS) stage (I, II, or III) for multiple myeloma from serum beta-2 microglobulin and albumin values per Greipp 2005 criteria.
Price / call$0.005
Success—
StatusUnknown
How this service works
Greipp 2005 International Staging System for multiple myeloma. Stage I: serum beta-2 microglobulin <3.5 mg/L and albumin >=3.5 g/dL. Stage III: beta-2 microglobulin >=5.5 mg/L. Stage II: neither I nor III. Returns iss_stage 1/2/3. Not a myeloma diagnosis or treatment choice; not R-ISS (no LDH, no cytogenetics); not trauma ISS. magent does not assay beta-2 microglobulin or albumin.
Output
Returns iss_stage as an integer (1, 2, or 3) representing the ISS stage per Greipp 2005: Stage I (beta-2 microglobulin <3.5 mg/L and albumin ≥3.5 g/dL), Stage III (beta-2 microglobulin ≥5.5 mg/L), and Stage II (neither I nor III).
Example use cases
Myeloma staging during oncology consult
“I have a myeloma patient with beta-2 microglobulin of 2.8 mg/L and albumin of 4.0 g/dL — what ISS stage are they?”
Automated staging in EHR pipeline
“For my patient with serum beta-2 microglobulin 6.1 mg/L and albumin 3.0 g/dL, calculate their Greipp 2005 ISS myeloma stage so I can document it in the chart.”
Research cohort risk stratification
“I need to assign ISS stages to a series of myeloma patients — starting with one who has beta-2 microglobulin 3.3 mg/L and albumin 3.6 g/dL, what stage do they get?”
Technical details
Endpoint
GEThttps://api.magentlab.com/api/calc/myeloma_issWhen to prefer
Use this endpoint when you need to apply the classic Greipp 2005 ISS criteria (Stage I/II/III) to lab values for multiple myeloma staging. Prefer this over R-ISS calculators when LDH and cytogenetics data are unavailable or not required. Do not use for trauma ISS scoring, myeloma diagnosis, or treatment selection.
Side effects
- Missing required beta2_microglobulin_mg_l parameter returns an error
- Providing both albumin_g_l and albumin_g_dl simultaneously is rejected
- Values outside accepted ranges (e.g. beta-2 microglobulin outside 0.2–40 mg/L, albumin outside 1–6 g/dL) may return validation errors
- No albumin provided when beta-2 microglobulin is below 5.5 and staging requires it may produce ambiguous output
Input
Schema · Request body
| Field | Type | Description |
|---|---|---|
| inputrequired | object | |
| output | object |
Output
Schema · Response
{
"type": "json",
"example": {
"path": "/api/calc/myeloma_iss",
"count": 2,
"items": [
{
"formula": "myeloma_iss",
"citation": {
"id": "greipp-2005",
"doi": "10.1200/JCO.2005.04.242",
"pmid": "15809451",
"title": "International staging system for multiple myeloma",
"source": "J Clin Oncol. 2005;23(15):3412-3420",
"authors": "Greipp PR, San Miguel J, Durie BGM, Crowley JJ, Barlogie B, Bladé J, Boccadoro M, Child JA, Avet-Loiseau H, Kyle RA, Lahuerta JJ, Ludwig H, Morgan G, Powles R, Shimizu K, Shustik C, Sonneveld P, Tosi P, Turesson I, Westin J"
},
"iss_stage": 1,
"disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
"albumin_g_dl": 4,
"iss_stage_label": "I",
"formula_expression": "ISS stage I: beta2_microglobulin_mg_l < 3.5 AND albumin_g_dl >= 3.5; stage III: beta2_microglobulin_mg_l >= 5.5; stage II: neither I nor III (Greipp 2005)",
"beta2_microglobulin_mg_l": 2
},
{
"formula": "myeloma_iss",
"citation": {
"id": "greipp-2005",
"doi": "10.1200/JCO.2005.04.242",
"pmid": "15809451",
"title": "International staging system for multiple myeloma",
"source": "J Clin Oncol. 2005;23(15):3412-3420",
"authors": "Greipp PR, San Miguel J, Durie BGM, Crowley JJ, Barlogie B, Bladé J, Boccadoro M, Child JA, Avet-Loiseau H, Kyle RA, Lahuerta JJ, Ludwig H, Morgan G, Powles R, Shimizu K, Shustik C, Sonneveld P, Tosi P, Turesson I, Westin J"
},
"iss_stage": 1,
"disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
"albumin_g_dl": 4,
"iss_stage_label": "I",
"formula_expression": "ISS stage I: beta2_microglobulin_mg_l < 3.5 AND albumin_g_dl >= 3.5; stage III: beta2_microglobulin_mg_l >= 5.5; stage II: neither I nor III (Greipp 2005)",
"beta2_microglobulin_mg_l": 2
}
]
}
}Tags
x402
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