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ClinVar Genetic Variants Lookup
x402
ClinVar Genetic Variants Lookup is a paid API for AI agents from health.memoryapi.org, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-13, last successful call 2026-07-19).
Returns pathogenic and benign ClinVar genetic variants for a given gene, including clinical significance and associated conditions.
Price / call$0.005
Success100%
StatusUnknown
How this service works
ClinVar genetic variants — pathogenic/benign variants for any gene with clinical significance and conditions.
Output
A list of genetic variants from ClinVar for the queried gene, each annotated with pathogenicity classification (e.g. pathogenic, benign, likely pathogenic), clinical significance details, and associated medical conditions or diseases.
Example use cases
Example prompt
“Can you pull all pathogenic and likely pathogenic ClinVar variants for the BRCA2 gene, along with the associated conditions they're linked to?”
Technical details
Endpoint
GEThttps://health.memoryapi.org/x402/health/variantsWhen to prefer
Use this endpoint when you need structured, curated clinical variant data from ClinVar — particularly when you need to know the pathogenicity classification and disease associations for variants in a specific gene. Prefer this over raw genome databases when clinical significance context is required.
Side effects
- Unknown or misspelled gene symbol returns empty result set
- Gene with no ClinVar entries returns empty array
- Invalid filter parameters may return 400 error
- Rate limiting or payment failure (x402) may block access
- Network timeout for genes with very large variant catalogs
Input
{
"limit": 10,
"country": "USA",
"indicator": "WHOSIS_000001"
}Schema · Request body
| Field | Type | Description |
|---|---|---|
| input | — |
Output
{
"gene": "BRCA1",
"count": 10,
"source": "NCBI ClinVar",
"success": true,
"variants": [
{
"url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/4850689/",
"title": "NM_007294.4(BRCA1):c.4185+1372T>G",
"gene_sort": "BRCA1",
"conditions": [],
"variation_id": "4850689"
},
{
"url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/4849514/",
"title": "NM_007294.4(BRCA1):c.1397_1406del (p.Arg466fs)",
"gene_sort": "BRCA1",
"conditions": [],
"variation_id": "4849514"
},
{
"url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/4848953/",
"title": "NM_007294.4(BRCA1):c.4091dup (p.Asn1364fs)",
"gene_sort": "BRCA1",
"conditions": [],
"variation_id": "4848953"
},
{
"url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/4845640/",
"title": "NM_007294.4(BRCA1):c.5556del (p.Tyr1853fs)",
"gene_sort": "BRCA1",
"conditions": [],
"variation_id": "4845640"
},
{
"url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/4845425/",
"title": "NM_007294.4(BRCA1):c.5193+123del",
"gene_sort": "BRCA1",
"conditions": [],
"variation_id": "4845425"
},
{
"url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/4842663/",
"title": "NM_007294.4(BRCA1):c.1772_1775del (p.Ile591fs)",
"gene_sort": "BRCA1",
"conditions": [],
"variation_id": "4842663"
},
{
"url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/4842662/",
"title": "NM_007294.4(BRCA1):c.4030_4031del (p.Asp1343_Asp1344insTer)",
"gene_sort": "BRCA1",
"conditions": [],
"variation_id": "4842662"
},
{
"url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/4842656/",
"title": "NM_007294.4(BRCA1):c.3050del (p.Glu1017fs)",
"gene_sort": "BRCA1",
"conditions": [],
"variation_id": "4842656"
},
{
"url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/4842655/",
"title": "NM_007294.4(BRCA1):c.2639_2646delinsG (p.Glu880fs)",
"gene_sort": "BRCA1",
"conditions": [],
"variation_id": "4842655"
},
{
"url": "https://www.ncbi.nlm.nih.gov/clinvar/variation/4826630/",
"title": "NM_007294.4(BRCA1):c.3189del (p.Ser1064fs)",
"gene_sort": "BRCA1",
"conditions": [],
"variation_id": "4826630"
}
],
"significance": "pathogenic"
}Schema · Response
{
"example": {
"gene": "BRCA1",
"count": 10,
"success": true,
"variants": [
{
"title": "NM_007294.4(BRCA1):c.68_69del (p.Glu23fs)",
"conditions": [
"Hereditary breast ovarian cancer syndrome"
],
"variation_id": "12345",
"clinical_significance": "Pathogenic"
}
],
"significance": "pathogenic"
}
}Tags
x402
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