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Hegele 2025 NAFCS Score Calculator (FCS Likelihood)
x402
Hegele 2025 NAFCS Score Calculator (FCS Likelihood) is a paid API for AI agents from api.magentlab.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-15).
Computes the Hegele 2025 North American Familial Chylomicronemia Syndrome (NAFCS) clinical score to estimate likelihood of classical FCS based on age, lipid values, BMI, and clinical history
Price / call$0.005
Success—
StatusUnknown
How this service works
Hegele 2025 NAFCS. Table 3 points from age or early HTG onset, BMI, abdominal pain or pancreatitis, secondary factors, fasting TG >880 mg/dL or >10 mmol/L, TG/TC >8 (mg/dL) or >3.5 (mmol/L), and apo B <1.0 g/L, plus published interactions. Max 100. ≥60 definite classical FCS; ≥45 very likely. Not a diagnosis or genetic test. Not Simon Broome or Dutch FH. magent does not examine the patient or assay lipids. Not a medical device.
Output
Returns an integer NAFCS score from 0–100 with a per-criterion point breakdown. Scores ≥60 indicate definite classical FCS; scores ≥45 indicate very likely FCS. The result is an arithmetic clinical scoring aid, not a diagnosis, genetic test, or output from a medical device.
Example use cases
Rare lipid disorder pre-screening
“I have a 28-year-old male patient, HTG onset before age 10, BMI below threshold, with recurrent abdominal pain (no pancreatitis), secondary factors present, fasting TGs at 950 mg/dL, TG/TC of 8.5, and apo B of 0.85 g/L — run the Hegele 2025 NAFCS score and tell me if he's likely classical FCS.”
Pediatric hypertriglyceridemia workup
“My patient is 7 years old with very high triglycerides — 1100 mg/dL fasting, TG/TC ratio of 9.2, apo B of 60 mg/dL, BMI below threshold, a history of abdominal pain, and secondary factors present. Can you compute the NAFCS score to see if this looks like familial chylomicronemia?”
Lipid clinic decision support
“For a 45-year-old female at our lipid clinic: no early HTG onset, BMI above threshold, no abdominal pain or pancreatitis, secondary factors absent, fasting TGs of 500 mg/dL, TG/TC of 5, and apo B of 1.2 g/L — what does the Hegele 2025 NAFCS scoring give her, and is she in the 'very likely' or 'definite' FCS range?”
Technical details
Endpoint
GEThttps://api.magentlab.com/api/calc/nafcsWhen to prefer
Use this endpoint when you need to apply the Hegele 2025 NAFCS clinical scoring table to estimate the likelihood of familial chylomicronemia syndrome (FCS/LPL deficiency) in a patient. Choose this over generic hypertriglyceridemia tools when the specific Hegele 2025 North American criteria (Table 3 point system) are required. Not appropriate for Simon Broome or Dutch FH scoring, genetic testing interpretation, or patients under 1 year of age.
Side effects
- Missing required parameters (age_years, htg_onset_before_age_10, bmi_below_threshold, abdominal_history, secondary_factors_present) returns a 400 error
- Providing both tg_mg_dl and tg_mmol_l simultaneously causes a validation error
- TG values outside range (mg/dL 440–20000 or mmol/L 5–226) rejected
- Age below 1 year not supported by the scoring model
- Providing both apo_b_g_l and apo_b_mg_dl simultaneously causes a validation error
- Payment failure (x402) results in 402 response requiring USDC payment
Input
Schema · Request body
| Field | Type | Description |
|---|---|---|
| inputrequired | object | |
| output | object |
Tags
x402
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