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HFA-ICOS Baseline Cardiovascular Risk Calculator (VEGF Inhibitors/TKIs)
x402
HFA-ICOS Baseline Cardiovascular Risk Calculator (VEGF Inhibitors/TKIs) is a paid API for AI agents from api.magentlab.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-14).
Classifies baseline cardiovascular risk (Very High / High / Medium / Low) before starting VEGF inhibitors or VEGF TKIs using the Lyon 2020 HFA-ICOS framework
Price / call$0.005
Success—
StatusUnknown
How this service works
Lyon 2020 HFA-ICOS baseline CV risk before VEGF inhibitors or VEGF TKIs. Very high if heart failure/cardiomyopathy or arterial vascular disease. High if venous thrombosis, LVEF <50%, QTc >=480 ms, age >=75, hypertension, prior anthracycline, or >=5 medium points. Medium if 2-4 medium points. Guide <2% / 2-9% / 10-19% / >=20%. Not a device or treatment order.
Output
Returns an HFA-ICOS cardiovascular risk tier (Very High, High, Medium, or Low) along with the count of medium-risk points and the corresponding guideline-based risk percentage band (<2%, 2–9%, 10–19%, or ≥20%) before initiating VEGF inhibitor or VEGF TKI therapy. Does not issue device or treatment orders.
Example use cases
Pre-sunitinib cardiac risk triage
“Before we start sunitinib, can you calculate the HFA-ICOS baseline CV risk for my 76-year-old male patient? He has hypertension and had prior anthracyclines, LVEF is 58%, QTc is 455 ms, no heart failure or cardiomyopathy, no arterial or venous disease, no arrhythmia, troponin normal, BNP normal, no diabetes, hyperlipidemia yes, no CKD, no proteinuria, no chest radiation, ex-smoker, BMI 32.”
Very high risk flag before bevacizumab
“Can you check the Lyon 2020 HFA-ICOS CV risk category for a 62-year-old female about to start bevacizumab? She has a history of heart failure and prior arterial vascular disease, LVEF 42%, QTc 470 ms, no venous thrombosis, hypertension yes, no anthracycline history, no arrhythmia, elevated troponin true, elevated BNP true, diabetes true, hyperlipidemia false, CKD false, proteinuria false, no mediastinal RT, non-smoker, BMI 27.”
Borderline QTc risk stratification
“I need the HFA-ICOS VEGF-inhibitor baseline risk for a 55-year-old male with QTc of 472 ms. He has no heart failure, no arterial or venous disease, LVEF 65%, not hypertensive, no prior anthracycline, no arrhythmia, troponin normal, BNP normal, no diabetes, hyperlipidemia false, no CKD, no proteinuria, no chest RT, non-smoker, BMI 24.”
Technical details
Endpoint
GEThttps://api.magentlab.com/api/calc/hfa_icos_vegfWhen to prefer
Use this endpoint when you need a structured, guideline-based (Lyon 2020 HFA-ICOS) cardiovascular risk classification specifically before initiating VEGF inhibitor or VEGF TKI therapy, and all required patient parameters are already assessed and available. Prefer this over general CV risk calculators (e.g. Framingham, SCORE) when the clinical question is cardio-oncology pre-treatment screening for anti-angiogenic agents.
Side effects
- Missing required parameters (age_years, sex, QTc, LVEF, or any boolean risk factor) returns a 400 validation error
- Out-of-range QTc (outside 300–700 ms) or age (outside 18–100) causes rejection
- Incorrect data types (non-integer for age or QTc, non-boolean for risk flags) result in schema validation failure
- Ambiguous sex value (not 'male' or 'female') breaks QTc borderline band assignment
Input
Schema · Request body
| Field | Type | Description |
|---|---|---|
| inputrequired | object | |
| output | object |
Tags
x402
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