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HFA-ICOS BCR-ABL Cardiovascular Risk Classifier (Lyon 2020)
x402
HFA-ICOS BCR-ABL Cardiovascular Risk Classifier (Lyon 2020) is a paid API for AI agents from api.magentlab.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-14).
Calculates the Lyon 2020 HFA-ICOS baseline cardiovascular risk category (very_high, high, medium, or low) prior to BCR-ABL-targeting TKI therapy for CML, based on published very-high, high, and medium risk factor criteria.
Price / call$0.005
Success—
StatusUnknown
How this service works
Lyon 2020 HFA-ICOS baseline cardiovascular risk before second- or third-generation multi-targeted kinase inhibitors for CML targeting BCR-ABL. Class is very_high, high, medium, or low from published very-high and high factors plus Medium 1/2 points (0–1 low, 2–4 medium, ≥5 high). Caller assigns the 10-year CVD >20% threshold; magent does not compute that score. Not a medical device or treatment order.
Output
Returns one of four risk classes — very_high, high, medium, or low — based on the Lyon 2020 HFA-ICOS BCR-ABL TKI cardiovascular risk table. The response reflects which very-high, high, or medium-point factors (Medium 1 and Medium 2) drove the classification, per the published scoring logic (0–1 = low, 2–4 = medium, ≥5 = high). Not a medical device output or treatment recommendation.
Example use cases
Pre-TKI cardiac risk triage in CML clinic
“Before we start this 72-year-old female CML patient on nilotinib, classify her HFA-ICOS cardiovascular risk — she has a QTc of 462 ms, LVEF of 55%, known arterial vascular disease, hypertension, and diabetes; no heart failure, no VTE, not obese, non-smoker, and I've assessed her 10-year CVD risk as above 20%.”
Cardio-oncology second opinion for high-risk CML patient
“I need a Lyon 2020 HFA-ICOS risk class for a 58-year-old male with a prior arterial thrombosis event on a TKI, pulmonary arterial hypertension, QTc of 490 ms, LVEF of 40%, and a history of venous thromboembolism — hypertensive and diabetic, BMI over 30, 10-year CVD risk below 20%.”
Automated EHR-integrated risk flagging for CML patients
“For our registry: 65-year-old female, QTc 470 ms, LVEF 62%, no arterial vascular disease, no prior TKI-related thrombosis, no heart failure, no arrhythmia, non-smoker, has CKD and hyperlipidemia, family history of thrombophilia, not obese, not diabetic, no VTE, no PAH, 10-year CVD risk not above 20% — what is her HFA-ICOS BCR-ABL risk class?”
Technical details
Endpoint
GEThttps://api.magentlab.com/api/calc/hfa_icos_bcr_ablWhen to prefer
Use this endpoint when you need a structured, rule-based Lyon 2020 HFA-ICOS cardiovascular risk class for a CML patient being evaluated for BCR-ABL TKI therapy (second- or third-generation, e.g. dasatinib, nilotinib, ponatinib). Prefer it over generic cardiovascular risk calculators (SCORE2, Framingham, PCE) because it applies the specific cardio-oncology factor table published for BCR-ABL inhibitors rather than general population risk models. It is appropriate when the caller has already assessed threshold values like eGFR, HbA1c, and 10-year CVD risk externally and needs the categorical risk class for documentation or clinical decision support workflows.
Side effects
- Missing required parameters (e.g. age_years, sex, qtc_ms, lvef_percent) returns a 400-level validation error
- QTc value outside the accepted 300–700 ms range is rejected
- age_years outside 18–100 range is rejected
- Boolean fields passed as strings rather than true/false may fail schema validation
- Caller-assigned threshold fields (e.g. cvd_10y_risk_gt_20, ckd, diabetes) not assessed by the API — incorrect caller assignment produces incorrect risk class
- Payment failure (x402) if USDC not provided correctly returns a 402 response
Input
Schema · Request body
| Field | Type | Description |
|---|---|---|
| inputrequired | object | |
| output | object |
Tags
x402
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