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HFA-ICOS RAF/MEK Inhibitor Baseline Cardiovascular Risk Calculator
x402
HFA-ICOS RAF/MEK Inhibitor Baseline Cardiovascular Risk Calculator is a paid API for AI agents from api.magentlab.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-14).
Classifies a patient's baseline cardiovascular risk (Very High / High / Medium / Low) before starting RAF and MEK inhibitor therapy, using the Lyon 2020 HFA-ICOS framework.
Price / call$0.005
Success—
StatusUnknown
How this service works
Lyon 2020 HFA-ICOS baseline CV risk before combination RAF and MEK inhibitors. Very high if heart failure or cardiomyopathy; High if MI/CABG, stable angina, severe valvular disease, prior anthracycline, or ≥5 medium points; Medium if 2-4 medium points; Low if 0-1. Age ≥65 is Medium 1 only. LVEF 50-54 is Medium 2; this table has no printed LVEF <50 High row. Expert-opinion cardiotoxicity guide <2% / 2-9% / 10-19% / ≥20%. Not a treatment order.
Output
Returns a categorical cardiovascular risk classification (Very High, High, Medium, or Low) based on the Lyon 2020 HFA-ICOS RAF/MEK table, along with the count of medium-risk points accumulated and a corresponding expert-opinion cardiotoxicity probability band (<2%, 2–9%, 10–19%, or ≥20%). This is an informational risk stratification output, not a treatment order.
Example use cases
Pre-RAF/MEK therapy cardiac triage
“My melanoma patient is 72 years old, LVEF 55%, with a past MI, no heart failure, no prior anthracyclines, has hypertension and type 2 diabetes (HbA1c well above 7%), no CKD, no arrhythmia, no prior chest radiation, no elevated troponin or BNP, not obese, not a smoker, and no significant angina or valvular disease — can you give me the Lyon 2020 HFA-ICOS cardiovascular risk classification before I start them on a RAF plus MEK inhibitor?”
Borderline LVEF pre-treatment risk check
“I have a 58-year-old patient with an LVEF of 52%, no cardiac history, no anthracycline exposure, no arrhythmia, no elevated troponin or BNP, no prior chest radiation, no hypertension, no diabetes, no CKD, not obese, and a non-smoker — what HFA-ICOS CV risk tier do they fall into before starting RAF and MEK inhibitors?”
High-burden comorbidity stratification
“Before we initiate combination RAF and MEK inhibitor therapy, classify the cardiac risk for a 61-year-old with a BMI of 33 (obese), CKD with eGFR below 60, atrial fibrillation, elevated BNP at baseline, no heart failure, no MI or CABG, no anthracyclines, LVEF of 58%, not a smoker, no diabetes, no hypertension, no prior radiation, and no valvular disease or angina.”
Technical details
Endpoint
GEThttps://api.magentlab.com/api/calc/hfa_icos_raf_mekWhen to prefer
Use this endpoint when you need to apply the specific Lyon 2020 HFA-ICOS cardiotoxicity risk classification framework for patients being considered for RAF and/or MEK inhibitor combination therapy. It implements the exact risk table with Very High / High / Medium / Low tiers and medium-point counting. Prefer this over generic cardiovascular risk calculators (e.g., Framingham, SCORE) when the clinical question is specifically about cardiotoxicity risk before targeted cancer therapy, not general population ASCVD risk.
Side effects
- Missing required boolean parameters returns a validation error
- Age outside 18–100 range is rejected
- LVEF values outside expected range may not be handled
- Ambiguous or non-boolean inputs for flag fields cause schema errors
- Network timeout or upstream server error returns a 5xx response
- Payment not included or insufficient returns a 402 Payment Required error
Input
Schema · Request body
| Field | Type | Description |
|---|---|---|
| inputrequired | object | |
| output | object |
Tags
x402
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