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ICC 2022 PMF Diagnostic Criteria Calculator (Arber 2022)
x402
ICC 2022 PMF Diagnostic Criteria Calculator (Arber 2022) is a paid API for AI agents from api.magentlab.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-15).
Evaluates whether a patient meets ICC 2022 (Arber 2022) diagnostic criteria for prefibrotic or overt primary myelofibrosis by checking 3 major and ≥1 minor criteria.
Price / call$0.005
Success—
StatusUnknown
How this service works
ICC 2022 prefibrotic and overt PMF (Arber 2022). Diagnosed iff 3 majors and ≥1 minor. Majors: megakaryocyte morphology, not another myeloid neoplasm, JAK2/CALR/MPL or other clone or no reactive fibrosis. Minors: anemia not from comorbidity, WBC ≥11e9/L, splenomegaly, LDH above ULN; leukoerythroblastosis counts only in overt PMF. Not DIPSS, MIPSS70, WHO 5th, or post-PV/post-ET MF. magent does not read fibrosis grade or sequence drivers. Not a diagnosis or medical device.
Output
Returns whether the patient meets ICC 2022 (Arber 2022) PMF diagnostic criteria (diagnosed or not), along with which major and minor criteria were satisfied and the total counts, for either prefibrotic or overt PMF phenotype.
Example use cases
Prefibrotic PMF workup in clinic
“I have a patient I've classified as prefibrotic PMF — megakaryocyte morphology is characteristic, JAK2 mutation present, no other myeloid neoplasm diagnosis, and they have anemia that isn't from any comorbidity and an elevated LDH. No splenomegaly, no leukocytosis. Do they satisfy ICC 2022 Arber prefibrotic PMF criteria?”
Overt PMF criteria check with leukoerythroblastosis
“Patient is phenotyped as overt PMF: megakaryocyte morphology abnormal, CALR mutation confirmed, not another myeloid neoplasm, and they have leukoerythroblastosis on peripheral smear plus splenomegaly. No anemia or leukocytosis independently noted. Can you run the ICC 2022 Arber 2022 overt PMF diagnostic checklist?”
Ruling in or out PMF for MPL-positive patient
“We have an MPL-mutated patient with no other identifiable myeloid neoplasm and characteristic megakaryocyte morphology — phenotype is prefibrotic. Their only minor criterion is WBC ≥11×10⁹/L. Do they meet the ICC 2022 PMF diagnostic threshold under Arber 2022?”
Technical details
Endpoint
GEThttps://api.magentlab.com/api/calc/icc_pmfWhen to prefer
Use this endpoint when you need to programmatically apply the ICC 2022 (Arber 2022) primary myelofibrosis diagnostic criteria to a set of caller-assigned clinical flags. Prefer it over manual checklists or other scoring tools when building hematology decision-support workflows, automating chart review, or auditing PMF diagnoses for consistency. Not suitable for DIPSS/MIPSS70 prognostication, WHO 5th edition criteria, or post-PV/post-ET MF evaluation.
Side effects
- Missing required query parameters returns a validation error
- Invalid enum value for phenotype (not 'pre' or 'overt') causes rejection
- Boolean fields provided as strings instead of booleans may fail schema validation
- Caller-assigned inputs that contradict clinical reality (e.g., leukoerythroblastosis counted for prefibrotic) may yield unexpected output since the API follows ICC rules per phenotype
- No result if network/payment (x402) fails
Input
Schema · Request body
| Field | Type | Description |
|---|---|---|
| inputrequired | object | |
| output | object |
Tags
x402
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