IMDC (Heng 2009) Risk Score Calculator

x402

IMDC (Heng 2009) Risk Score Calculator is a paid API for AI agents from api.magentlab.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-15).

Computes the International Metastatic RCC Database Consortium (IMDC) prognostic risk score and risk group (favorable/intermediate/poor) from six caller-supplied boolean clinical flags.

Price / call$0.005

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How this service works

Heng 2009 IMDC: KPS <80, diagnosis-to-treatment <1 year, hemoglobin <LLN, corrected calcium >ULN, neutrophils >ULN, platelets >ULN; 1 point each, max 6. Favorable 0, intermediate 1–2, poor ≥3. Deterministic published score with citation; not an RCC diagnosis or treatment recommendation. magent does not assign KPS or compare Hb, Ca, ANC, or platelets to institutional LLN/ULN.

Output

Returns the computed IMDC total score (0–6) and the corresponding risk group classification: favorable (0 points), intermediate (1–2 points), or poor (≥3 points), based on the Heng 2009 publication. The endpoint performs arithmetic aggregation only; it does not interpret raw lab values or assign KPS.

Example use cases

Oncology trial eligibility stratification

“I need the IMDC risk group for a metastatic kidney cancer patient before enrollment — KPS under 80 is true, diagnosis-to-treatment under 1 year is true, hemoglobin below LLN is true, corrected calcium above ULN is false, neutrophils above ULN is false, platelets above ULN is false. What's their risk category?”

Tumor board prognostic summary

“For our tumor board presentation, can you compute the Heng 2009 IMDC score for a patient where KPS <80 is false, diagnosis-to-treatment <1 year is false, hemoglobin below LLN is false, corrected calcium above ULN is false, neutrophils above ULN is false, and platelets above ULN is false? I want to confirm they're favorable risk.”

Treatment planning risk assessment

“Before starting first-line therapy for this mRCC patient, give me their IMDC prognostic score: KPS <80 yes, diagnosis-to-treatment <1 year yes, low hemoglobin yes, high corrected calcium yes, high neutrophils yes, high platelets yes.”

Technical details

Endpoint

GEThttps://api.magentlab.com/api/calc/imdc

When to prefer

Use this endpoint when you have already evaluated all six IMDC criteria (KPS, diagnosis-to-treatment interval, hemoglobin vs LLN, corrected calcium vs ULN, neutrophils vs ULN, platelets vs ULN) and need a fast, deterministic, citation-backed score computation without building the arithmetic yourself. Prefer it over general LLM reasoning for reproducibility and auditability in clinical or research workflows. Do not use it as a substitute for physician assessment or if you need raw-value comparison against institutional reference ranges.

Side effects

Missing required boolean query parameter returns validation error
Non-boolean value for any flag causes schema rejection
Network timeout on rare infrastructure issues
Incorrect caller-assigned flags (e.g. wrong LLN/ULN threshold) produce a valid but clinically incorrect score — the API cannot detect this

Input

Schema · Request body

Field	Type	Description
inputrequired	object
output	object

Output

Schema · Response

{
  "type": "json",
  "example": {
    "path": "/api/calc/imdc",
    "count": 2,
    "items": [
      {
        "score": 0,
        "formula": "imdc",
        "citation": {
          "id": "heng-2009",
          "doi": "10.1200/JCO.2008.21.4809",
          "pmid": "19826129",
          "title": "Prognostic factors for overall survival in patients with metastatic renal cell carcinoma treated with vascular endothelial growth factor-targeted agents: results from a large, multicenter study",
          "source": "J Clin Oncol. 2009;27(34):5794-5799",
          "authors": "Heng DY, Xie W, Regan MM, Warren MA, Golshayan AR, Sahi C, Eigl BJ, Ruether JD, Cheng T, North S, Venner P, Knox JJ, Chi KN, Kollmannsberger C, McDermott DF, Rini BI, Bukowski RM, Rha SY, Choueiri TK"
        },
        "imdc_band": "favorable",
        "max_score": 6,
        "components": [
          {
            "factor": "kps_lt_80",
            "points": 0,
            "present": false
          },
          {
            "factor": "diagnosis_to_treatment_lt_1_year",
            "points": 0,
            "present": false
          },
          {
            "factor": "hemoglobin_lt_lln",
            "points": 0,
            "present": false
          },
          {
            "factor": "corrected_calcium_gt_uln",
            "points": 0,
            "present": false
          },
          {
            "factor": "neutrophils_gt_uln",
            "points": 0,
            "present": false
          },
          {
            "factor": "platelets_gt_uln",
            "points": 0,
            "present": false
          }
        ],
        "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
        "formula_expression": "IMDC = kps_lt_80 1 + diagnosis_to_treatment_lt_1_year 1 + hemoglobin_lt_lln 1 + corrected_calcium_gt_uln 1 + neutrophils_gt_uln 1 + platelets_gt_uln 1; Heng 2009; max 6; favorable 0, intermediate 1-2, poor ≥3"
      },
      {
        "score": 0,
        "formula": "imdc",
        "citation": {
          "id": "heng-2009",
          "doi": "10.1200/JCO.2008.21.4809",
          "pmid": "19826129",
          "title": "Prognostic factors for overall survival in patients with metastatic renal cell carcinoma treated with vascular endothelial growth factor-targeted agents: results from a large, multicenter study",
          "source": "J Clin Oncol. 2009;27(34):5794-5799",
          "authors": "Heng DY, Xie W, Regan MM, Warren MA, Golshayan AR, Sahi C, Eigl BJ, Ruether JD, Cheng T, North S, Venner P, Knox JJ, Chi KN, Kollmannsberger C, McDermott DF, Rini BI, Bukowski RM, Rha SY, Choueiri TK"
        },
        "imdc_band": "favorable",
        "max_score": 6,
        "components": [
          {
            "factor": "kps_lt_80",
            "points": 0,
            "present": false
          },
          {
            "factor": "diagnosis_to_treatment_lt_1_year",
            "points": 0,
            "present": false
          },
          {
            "factor": "hemoglobin_lt_lln",
            "points": 0,
            "present": false
          },
          {
            "factor": "corrected_calcium_gt_uln",
            "points": 0,
            "present": false
          },
          {
            "factor": "neutrophils_gt_uln",
            "points": 0,
            "present": false
          },
          {
            "factor": "platelets_gt_uln",
            "points": 0,
            "present": false
          }
        ],
        "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
        "formula_expression": "IMDC = kps_lt_80 1 + diagnosis_to_treatment_lt_1_year 1 + hemoglobin_lt_lln 1 + corrected_calcium_gt_uln 1 + neutrophils_gt_uln 1 + platelets_gt_uln 1; Heng 2009; max 6; favorable 0, intermediate 1-2, poor ≥3"
      }
    ]
  }
}

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How this service works

Output

Example use cases

Oncology trial eligibility stratification

Tumor board prognostic summary

Treatment planning risk assessment

Technical details

Endpoint

GEThttps://api.magentlab.com/api/calc/imdc

When to prefer

Side effects

Missing required boolean query parameter returns validation error
Non-boolean value for any flag causes schema rejection
Network timeout on rare infrastructure issues
Incorrect caller-assigned flags (e.g. wrong LLN/ULN threshold) produce a valid but clinically incorrect score — the API cannot detect this

Input

Schema · Request body

Field	Type	Description
inputrequired	object
output	object

Output

Schema · Response

{
  "type": "json",
  "example": {
    "path": "/api/calc/imdc",
    "count": 2,
    "items": [
      {
        "score": 0,
        "formula": "imdc",
        "citation": {
          "id": "heng-2009",
          "doi": "10.1200/JCO.2008.21.4809",
          "pmid": "19826129",
          "title": "Prognostic factors for overall survival in patients with metastatic renal cell carcinoma treated with vascular endothelial growth factor-targeted agents: results from a large, multicenter study",
          "source": "J Clin Oncol. 2009;27(34):5794-5799",
          "authors": "Heng DY, Xie W, Regan MM, Warren MA, Golshayan AR, Sahi C, Eigl BJ, Ruether JD, Cheng T, North S, Venner P, Knox JJ, Chi KN, Kollmannsberger C, McDermott DF, Rini BI, Bukowski RM, Rha SY, Choueiri TK"
        },
        "imdc_band": "favorable",
        "max_score": 6,
        "components": [
          {
            "factor": "kps_lt_80",
            "points": 0,
            "present": false
          },
          {
            "factor": "diagnosis_to_treatment_lt_1_year",
            "points": 0,
            "present": false
          },
          {
            "factor": "hemoglobin_lt_lln",
            "points": 0,
            "present": false
          },
          {
            "factor": "corrected_calcium_gt_uln",
            "points": 0,
            "present": false
          },
          {
            "factor": "neutrophils_gt_uln",
            "points": 0,
            "present": false
          },
          {
            "factor": "platelets_gt_uln",
            "points": 0,
            "present": false
          }
        ],
        "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
        "formula_expression": "IMDC = kps_lt_80 1 + diagnosis_to_treatment_lt_1_year 1 + hemoglobin_lt_lln 1 + corrected_calcium_gt_uln 1 + neutrophils_gt_uln 1 + platelets_gt_uln 1; Heng 2009; max 6; favorable 0, intermediate 1-2, poor ≥3"
      },
      {
        "score": 0,
        "formula": "imdc",
        "citation": {
          "id": "heng-2009",
          "doi": "10.1200/JCO.2008.21.4809",
          "pmid": "19826129",
          "title": "Prognostic factors for overall survival in patients with metastatic renal cell carcinoma treated with vascular endothelial growth factor-targeted agents: results from a large, multicenter study",
          "source": "J Clin Oncol. 2009;27(34):5794-5799",
          "authors": "Heng DY, Xie W, Regan MM, Warren MA, Golshayan AR, Sahi C, Eigl BJ, Ruether JD, Cheng T, North S, Venner P, Knox JJ, Chi KN, Kollmannsberger C, McDermott DF, Rini BI, Bukowski RM, Rha SY, Choueiri TK"
        },
        "imdc_band": "favorable",
        "max_score": 6,
        "components": [
          {
            "factor": "kps_lt_80",
            "points": 0,
            "present": false
          },
          {
            "factor": "diagnosis_to_treatment_lt_1_year",
            "points": 0,
            "present": false
          },
          {
            "factor": "hemoglobin_lt_lln",
            "points": 0,
            "present": false
          },
          {
            "factor": "corrected_calcium_gt_uln",
            "points": 0,
            "present": false
          },
          {
            "factor": "neutrophils_gt_uln",
            "points": 0,
            "present": false
          },
          {
            "factor": "platelets_gt_uln",
            "points": 0,
            "present": false
          }
        ],
        "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
        "formula_expression": "IMDC = kps_lt_80 1 + diagnosis_to_treatment_lt_1_year 1 + hemoglobin_lt_lln 1 + corrected_calcium_gt_uln 1 + neutrophils_gt_uln 1 + platelets_gt_uln 1; Heng 2009; max 6; favorable 0, intermediate 1-2, poor ≥3"
      }
    ]
  }
}