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IMWG 2014 Multiple Myeloma Requiring Therapy Criteria Calculator
x402
IMWG 2014 Multiple Myeloma Requiring Therapy Criteria Calculator is a paid API for AI agents from api.magentlab.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-14).
Evaluates IMWG 2014 criteria (Rajkumar 2014) to determine whether a patient meets the definition of multiple myeloma requiring therapy based on CRAB features and SLiM biomarkers
Price / call$0.005
Success—
StatusUnknown
How this service works
IMWG 2014 myeloma requiring therapy (Rajkumar 2014). Met when clonal BMPC ≥10% or biopsy-proven plasmacytoma plus ≥1 MDE: hypercalcemia, renal insufficiency, anemia, osteolytic lesion (CRAB), or BMPC ≥60%, involved:uninvolved FLC ratio ≥100 with involved FLC ≥100 mg/L, or >1 focal MRI lesion ≥5 mm (SLiM). Not a diagnosis. Not smouldering MM, MGUS, POEMS, or amyloid. Not Greipp ISS or R-ISS. magent does not assay calcium, creatinine, hemoglobin, or FLC, and does not read MRI.
Output
Returns a structured classification indicating whether the patient meets the IMWG 2014 definition of multiple myeloma requiring therapy, which CRAB features (hypercalcemia, renal insufficiency, anemia, osteolytic lesion) are satisfied, and which SLiM biomarkers (BMPC ≥60%, FLC ratio ≥100, MRI focal lesions) are satisfied. The endpoint does not diagnose; it applies the Rajkumar 2014 rule to caller-assigned Boolean inputs.
Example use cases
Active myeloma vs smouldering classification
“My hematology patient has bone marrow biopsy showing clonal plasma cells ≥10%, serum calcium is elevated above 2.75 mmol/L so hypercalcemia is true, no renal issues, no anemia, no bone lesions, BMPC is under 60%, FLC ratio is below 100, and MRI shows no focal lesions — does this meet IMWG 2014 myeloma requiring therapy criteria?”
SLiM biomarker–driven myeloma flagging
“A patient's marrow shows clonal plasma cells ≥10%, no hypercalcemia, no renal insufficiency, no anemia, no osteolytic lesions, but BMPC is ≥60% — does that alone satisfy the Rajkumar 2014 SLiM criteria for active myeloma requiring treatment?”
Treatment eligibility check at MDT review
“At our multidisciplinary tumor board we have a patient with biopsy-proven plasmacytoma, no hypercalcemia, renal insufficiency is true, no anemia, one osteolytic lesion confirmed on CT, BMPC under 60%, FLC ratio under 100, and MRI showing two focal lesions each ≥5 mm — can you run the IMWG 2014 myeloma requiring therapy rule for this case?”
Technical details
Endpoint
GEThttps://api.magentlab.com/api/calc/imwg_myelomaWhen to prefer
Use this endpoint when you have already interpreted lab values, imaging, and marrow results and need to programmatically apply the IMWG 2014 Rajkumar criteria to determine if a patient crosses the threshold for myeloma requiring therapy. Prefer it over manual rule application when building clinical decision support pipelines, EHR integrations, or oncology workflow automation. Do not use it if you need staging (ISS/R-ISS), lab assaying, MRI interpretation, or differential diagnosis between plasma cell dyscrasias.
Side effects
- Missing required Boolean flags returns a validation error
- Incorrect data types for Boolean parameters cause rejection
- Endpoint does not assay lab values — callers must pre-assign CRAB and SLiM flags from their own data sources
- Does not apply ISS, R-ISS, or staging — only myeloma-requiring-therapy classification
- Will not distinguish MGUS, smouldering MM, POEMS, or amyloid — those require separate logic
Input
Schema · Request body
| Field | Type | Description |
|---|---|---|
| inputrequired | object | |
| output | object |
Tags
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