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IWG-2 Typical Alzheimer's Disease Criteria Calculator (Dubois 2014)
x402
IWG-2 Typical Alzheimer's Disease Criteria Calculator (Dubois 2014) is a paid API for AI agents from api.magentlab.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-15).
Applies the Dubois 2014 IWG-2 criteria to determine whether a patient meets the definition of typical Alzheimer's disease based on caller-supplied clinical flags.
Price / call$0.005
Success—
StatusUnknown
How this service works
Dubois 2014 IWG-2 typical AD research criteria. typical_ad iff early hippocampal-type episodic memory, no better explanation, and in-vivo AD pathology (CSF Abeta1-42 plus T-tau or P-tau, amyloid PET, or a PSEN1/PSEN2/APP mutation). Typical AD only; not atypical phenotypes. Not NINCDS-ADRDA, not NIA-AA ATN, not DSM. magent does not examine the patient, assay CSF, or read PET. Not a diagnosis or medical device.
Output
Returns a boolean classification indicating whether the patient meets the Dubois 2014 IWG-2 definition of typical Alzheimer's disease (typical_ad: true/false), based on the five caller-supplied flags: early hippocampal-type episodic memory impairment, CSF Abeta/tau pathology, amyloid PET positivity, autosomal dominant mutation, and absence of a better explanation.
Example use cases
Research cohort AD eligibility screening
“I need to check if this research participant qualifies as typical AD under Dubois 2014 IWG-2: they have early hippocampal-type episodic memory impairment, their CSF shows decreased Abeta1-42 and elevated tau, amyloid PET is negative, no PSEN1/PSEN2/APP mutation confirmed, and no better explanation for the presentation.”
Clinical trial enrollment decision support
“Can you run the IWG-2 typical AD check for a patient being considered for a trial? They have early episodic memory impairment of hippocampal type, their amyloid PET is positive, CSF biomarkers are not available, no autosomal dominant mutation found, and other diagnoses have been excluded.”
Automated AD classification in EHR pipeline
“For this patient record, apply the 2014 Dubois IWG-2 criteria: early hippocampal episodic memory impairment is true, CSF Abeta1-42 plus tau is false, amyloid PET is false, autosomal dominant mutation is true, and no better explanation is true — do they meet typical AD?”
Technical details
Endpoint
GEThttps://api.magentlab.com/api/calc/iwg2_adWhen to prefer
Use this endpoint when you need to programmatically apply the specific Dubois 2014 IWG-2 criteria for typical Alzheimer's disease — not NIA-AA ATN, not NINCDS-ADRDA, not DSM. Ideal for research pipelines, clinical trial screening workflows, or EHR automation where a clinician or upstream system has already assigned the five binary clinical flags and you need a rule-based IWG-2 classification without manual lookup.
Side effects
- Missing required query parameters (early_episodic_memory, csf_abeta_and_tau, amyloid_pet, autosomal_dominant_mutation, no_better_explanation) returns an error
- Non-boolean values for any flag cause a validation error
- Atypical AD phenotypes are outside scope and will not be correctly classified
- Endpoint cannot generate or verify the underlying clinical data — garbage-in, garbage-out if flags are incorrectly assigned by the caller
Input
Schema · Request body
| Field | Type | Description |
|---|---|---|
| inputrequired | object | |
| output | object |
Tags
x402
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