King's College Criteria Calculator for Fulminant Hepatic Failure

x402

King's College Criteria Calculator for Fulminant Hepatic Failure is a paid API for AI agents from api.magentlab.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-15).

Applies the King's College Hospital (O'Grady 1989) poor-prognosis criteria for fulminant hepatic failure, supporting both acetaminophen and non-acetaminophen etiologies using prothrombin time in seconds.

Price / call$0.005

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How this service works

King's College criteria (O'Grady 1989) for poor prognosis in fulminant hepatic failure. Acetaminophen: arterial pH <7.30, or PT >100 s plus creatinine >300 umol/L plus grade III/IV encephalopathy. Non-acetaminophen: PT >100 s, or any 3 of age <11 or >40, unfavorable etiology (non-A non-B or drug reaction), jaundice-to-encephalopathy >7 days, bilirubin >300 umol/L, PT >50 s. PT seconds, not INR. Not a transplant listing order.

Output

Returns a structured result indicating whether the patient meets the King's College poor-prognosis criteria for fulminant hepatic failure, which tree was applied (acetaminophen vs. non-acetaminophen), which individual criteria were met or not met, and an overall poor-prognosis flag. Does not constitute a transplant listing order.

Example use cases

Acetaminophen overdose ICU prognosis

“My ICU patient took a Tylenol overdose — arterial pH is 7.28, PT is 112 seconds, creatinine is 320 umol/L, and encephalopathy grade is IV. Age is 34. Run the King's College acetaminophen criteria and tell me if they meet the poor prognosis threshold.”

Non-acetaminophen hepatitis poor prognosis check

“I have a 52-year-old with non-A non-B hepatitis — PT is 55 seconds, bilirubin is 310 umol/L, encephalopathy grade is II, jaundice appeared 10 days before encephalopathy, arterial pH 7.38, creatinine 130 umol/L. Does this patient meet King's College non-acetaminophen poor prognosis criteria?”

Drug-induced liver failure transplant evaluation triage

“Patient has drug-reaction fulminant hepatic failure, age 9, PT 108 seconds, bilirubin 280 umol/L, grade III encephalopathy, pH 7.40, creatinine 95 umol/L, jaundice-to-encephalopathy 8 days. Use the King's College O'Grady 1989 non-acetaminophen tree to see if they meet poor prognosis criteria.”

Technical details

Endpoint

GEThttps://api.magentlab.com/api/calc/kings_college

When to prefer

Use this endpoint when you need a reproducible, evidence-based computation of the King's College (O'Grady 1989) poor-prognosis criteria for fulminant hepatic failure, specifically when PT is expressed in seconds (not INR). Prefer this over manual calculation to avoid transcription errors, and over generic liver scoring tools (MELD, Child-Pugh) when the clinical question is specifically whether a patient meets King's College criteria for transplant evaluation referral.

Side effects

Missing required query parameters returns a validation error
PT supplied as INR instead of seconds will produce incorrect scoring — INR is explicitly not accepted
Etiology field missing causes request to fail
Values outside accepted numeric ranges (e.g. pH outside 6.80-7.80) may cause rejection or inaccurate results
Encephalopathy grade outside 0-4 integer range causes validation failure

Input

Schema · Request body

Field	Type	Description
inputrequired	object
output	object

Output

Schema · Response

{
  "type": "json",
  "example": {
    "path": "/api/calc/kings_college",
    "count": 2,
    "items": [
      {
        "formula": "kings_college",
        "citation": {
          "id": "ogrady-1989",
          "doi": "10.1016/0016-5085(89)90081-4",
          "pmid": "2490426",
          "title": "Early indicators of prognosis in fulminant hepatic failure",
          "source": "Gastroenterology. 1989;97(2):439-445",
          "authors": "O'Grady JG, Alexander GJ, Hayllar KM, Williams R"
        },
        "criteria": [
          {
            "met": false,
            "value": 7.4,
            "factor": "arterial_ph_lt_7_30"
          },
          {
            "met": false,
            "value": 20,
            "factor": "pt_sec_gt_100"
          },
          {
            "met": false,
            "value": 80,
            "factor": "creatinine_umol_l_gt_300"
          },
          {
            "met": false,
            "value": 1,
            "factor": "encephalopathy_grade_ge_3"
          }
        ],
        "etiology": "acetaminophen",
        "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
        "criteria_met": false,
        "formula_expression": "acetaminophen: arterial_ph < 7.30, or (pt_sec > 100 and creatinine_umol_l > 300 and encephalopathy_grade >= 3); non_acetaminophen: pt_sec > 100, or at least 3 of (age_years < 11 or > 40; unfavorable_etiology; jaundice_to_encephalopathy_days > 7; bilirubin_umol_l > 300; pt_sec > 50)"
      },
      {
        "formula": "kings_college",
        "citation": {
          "id": "ogrady-1989",
          "doi": "10.1016/0016-5085(89)90081-4",
          "pmid": "2490426",
          "title": "Early indicators of prognosis in fulminant hepatic failure",
          "source": "Gastroenterology. 1989;97(2):439-445",
          "authors": "O'Grady JG, Alexander GJ, Hayllar KM, Williams R"
        },
        "criteria": [
          {
            "met": false,
            "value": 7.4,
            "factor": "arterial_ph_lt_7_30"
          },
          {
            "met": false,
            "value": 20,
            "factor": "pt_sec_gt_100"
          },
          {
            "met": false,
            "value": 80,
            "factor": "creatinine_umol_l_gt_300"
          },
          {
            "met": false,
            "value": 1,
            "factor": "encephalopathy_grade_ge_3"
          }
        ],
        "etiology": "acetaminophen",
        "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
        "criteria_met": false,
        "formula_expression": "acetaminophen: arterial_ph < 7.30, or (pt_sec > 100 and creatinine_umol_l > 300 and encephalopathy_grade >= 3); non_acetaminophen: pt_sec > 100, or at least 3 of (age_years < 11 or > 40; unfavorable_etiology; jaundice_to_encephalopathy_days > 7; bilirubin_umol_l > 300; pt_sec > 50)"
      }
    ]
  }
}

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How this service works

Output

Example use cases

Acetaminophen overdose ICU prognosis

Non-acetaminophen hepatitis poor prognosis check

Drug-induced liver failure transplant evaluation triage

Technical details

Endpoint

GEThttps://api.magentlab.com/api/calc/kings_college

When to prefer

Side effects

Missing required query parameters returns a validation error
PT supplied as INR instead of seconds will produce incorrect scoring — INR is explicitly not accepted
Etiology field missing causes request to fail
Values outside accepted numeric ranges (e.g. pH outside 6.80-7.80) may cause rejection or inaccurate results
Encephalopathy grade outside 0-4 integer range causes validation failure

Input

Schema · Request body

Field	Type	Description
inputrequired	object
output	object

Output

Schema · Response

{
  "type": "json",
  "example": {
    "path": "/api/calc/kings_college",
    "count": 2,
    "items": [
      {
        "formula": "kings_college",
        "citation": {
          "id": "ogrady-1989",
          "doi": "10.1016/0016-5085(89)90081-4",
          "pmid": "2490426",
          "title": "Early indicators of prognosis in fulminant hepatic failure",
          "source": "Gastroenterology. 1989;97(2):439-445",
          "authors": "O'Grady JG, Alexander GJ, Hayllar KM, Williams R"
        },
        "criteria": [
          {
            "met": false,
            "value": 7.4,
            "factor": "arterial_ph_lt_7_30"
          },
          {
            "met": false,
            "value": 20,
            "factor": "pt_sec_gt_100"
          },
          {
            "met": false,
            "value": 80,
            "factor": "creatinine_umol_l_gt_300"
          },
          {
            "met": false,
            "value": 1,
            "factor": "encephalopathy_grade_ge_3"
          }
        ],
        "etiology": "acetaminophen",
        "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
        "criteria_met": false,
        "formula_expression": "acetaminophen: arterial_ph < 7.30, or (pt_sec > 100 and creatinine_umol_l > 300 and encephalopathy_grade >= 3); non_acetaminophen: pt_sec > 100, or at least 3 of (age_years < 11 or > 40; unfavorable_etiology; jaundice_to_encephalopathy_days > 7; bilirubin_umol_l > 300; pt_sec > 50)"
      },
      {
        "formula": "kings_college",
        "citation": {
          "id": "ogrady-1989",
          "doi": "10.1016/0016-5085(89)90081-4",
          "pmid": "2490426",
          "title": "Early indicators of prognosis in fulminant hepatic failure",
          "source": "Gastroenterology. 1989;97(2):439-445",
          "authors": "O'Grady JG, Alexander GJ, Hayllar KM, Williams R"
        },
        "criteria": [
          {
            "met": false,
            "value": 7.4,
            "factor": "arterial_ph_lt_7_30"
          },
          {
            "met": false,
            "value": 20,
            "factor": "pt_sec_gt_100"
          },
          {
            "met": false,
            "value": 80,
            "factor": "creatinine_umol_l_gt_300"
          },
          {
            "met": false,
            "value": 1,
            "factor": "encephalopathy_grade_ge_3"
          }
        ],
        "etiology": "acetaminophen",
        "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
        "criteria_met": false,
        "formula_expression": "acetaminophen: arterial_ph < 7.30, or (pt_sec > 100 and creatinine_umol_l > 300 and encephalopathy_grade >= 3); non_acetaminophen: pt_sec > 100, or at least 3 of (age_years < 11 or > 40; unfavorable_etiology; jaundice_to_encephalopathy_days > 7; bilirubin_umol_l > 300; pt_sec > 50)"
      }
    ]
  }
}