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Maddrey Discriminant Function Calculator
x402
Maddrey Discriminant Function Calculator is a paid API for AI agents from api.magentlab.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-15).
Computes the Maddrey Discriminant Function (MDF) score for alcoholic hepatitis severity from patient and control prothrombin times and serum bilirubin
Price / call$0.005
Success—
StatusUnknown
How this service works
Maddrey discriminant function (1978) from patient and control prothrombin time in seconds plus bilirubin. Deterministic published formula with citation; not a diagnosis or steroid order.
Output
Returns the calculated Maddrey Discriminant Function score (a numeric value where ≥32 indicates severe alcoholic hepatitis per the 1978 Maddrey publication), along with the formula applied, input values used, and a bibliographic citation. Does not provide a diagnosis or steroid treatment recommendation.
Example use cases
Alcoholic hepatitis severity triage
“My patient has alcoholic hepatitis — PT is 19.5 seconds, control PT is 11 seconds, and total bilirubin is 8.4 mg/dL. What's their Maddrey discriminant function score?”
Bilirubin in µmol/L conversion case
“Can you run the Maddrey formula for a patient whose PT is 25 seconds, control PT is 12 seconds, and bilirubin is 210 µmol/L? I need the MDF result.”
Borderline MDF threshold check
“I have a patient with PT 14.5 seconds, lab control PT of 11.5 seconds, and bilirubin of 6 mg/dL — compute their Maddrey score so I can see if they're above or below 32.”
Technical details
Endpoint
GEThttps://api.magentlab.com/api/calc/maddreyWhen to prefer
Use this endpoint when you need a deterministic, citation-backed Maddrey Discriminant Function score computed from raw prothrombin times in seconds (not INR) and serum bilirubin. Prefer this over manual calculation to avoid arithmetic errors and to get a structured, citable result. It is not appropriate for endpoints requiring INR input, MELD score calculation, or clinical decision output beyond the MDF formula itself.
Side effects
- Missing required parameters (pt_patient_sec or pt_control_sec) returns a validation error
- Bilirubin not provided in either mg/dL or µmol/L returns an error
- Out-of-range values (e.g. PT control outside 8-20 sec, bilirubin outside 0.1-40 mg/dL) may return a validation error
- INR values submitted instead of PT seconds are not accepted and will produce incorrect or rejected results
- Payment not included or invalid x402 payment returns 402 Payment Required
Input
Schema · Request body
| Field | Type | Description |
|---|---|---|
| inputrequired | object | |
| output | object |
Output
Schema · Response
{
"type": "json",
"example": {
"path": "/api/calc/maddrey",
"count": 2,
"items": [
{
"df": 44.8,
"formula": "maddrey_1978",
"citation": {
"id": "maddrey-1978",
"doi": "10.1016/0016-5085(78)90401-8",
"title": "Corticosteroid therapy of alcoholic hepatitis",
"source": "Gastroenterology. 1978;75(2):193-199",
"authors": "Maddrey WC, Boitnott JK, Bedine MS, Weber FL Jr, Mezey E, White RI Jr"
},
"disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
"pt_control_sec": 12,
"pt_patient_sec": 20,
"bilirubin_mg_dl": 8,
"formula_expression": "DF = 4.6 * (pt_patient_sec - pt_control_sec) + bilirubin_mg_dl"
},
{
"df": 44.8,
"formula": "maddrey_1978",
"citation": {
"id": "maddrey-1978",
"doi": "10.1016/0016-5085(78)90401-8",
"title": "Corticosteroid therapy of alcoholic hepatitis",
"source": "Gastroenterology. 1978;75(2):193-199",
"authors": "Maddrey WC, Boitnott JK, Bedine MS, Weber FL Jr, Mezey E, White RI Jr"
},
"disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
"pt_control_sec": 12,
"pt_patient_sec": 20,
"bilirubin_mg_dl": 8,
"formula_expression": "DF = 4.6 * (pt_patient_sec - pt_control_sec) + bilirubin_mg_dl"
}
]
}
}Tags
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