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magent ASCO 2018 Immune-Related Hepatitis (irAE) Grader
x402
magent ASCO 2018 Immune-Related Hepatitis (irAE) Grader is a paid API for AI agents from api.magentlab.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-14).
Grades immune-related hepatitis severity per ASCO 2018 Brahmer guidelines from AST, ALT, and total bilirubin values, and returns the ICI management action (continue, hold, or permanently discontinue).
Price / call$0.005
Success—
StatusUnknown
How this service works
ASCO 2018 (Brahmer) immune-related hepatitis grade from caller AST, ALT, and total bilirubin as folds of laboratory ULN (mg/dL only). Lab grade is the max of transaminase and bilirubin Table 2.2 bands; decompensated liver upgrades to grade 4; symptomatic compensated liver dysfunction upgrades to grade 3. ICI action: continue (0-1), hold (2), or permanently discontinue (3-4). Not a medical device, not a diagnosis, not DILI/RUCAM, not R factor, not a steroid dose; magent does not assay enzymes.
Output
Returns the computed irAE hepatitis grade (0–4) per ASCO 2018 Brahmer Table 2.2, including the underlying lab grade derived from max transaminase and bilirubin fold-over-ULN, any clinical upgrades applied (decompensated → grade 4; symptomatic → grade 3), and the recommended ICI management action: continue (grade 0–1), hold (grade 2), or permanently discontinue (grade 3–4).
Example use cases
ICI hold decision during immunotherapy
“My melanoma patient on pembrolizumab has an AST of 250 U/L (ULN 40), ALT of 310 U/L (ULN 40), bilirubin 2.1 mg/dL (ULN 1.2) — no decompensation, no symptoms. What's the ASCO 2018 irAE hepatitis grade and should we hold the drug?”
Decompensated liver upgrade check
“Can you grade the immune-related hepatitis for a patient with AST 95 U/L (ULN 40), ALT 110 U/L (ULN 40), bilirubin 1.5 mg/dL (ULN 1.0), who has ascites indicating decompensated liver disease? No symptomatic dysfunction otherwise.”
Borderline transaminase elevation triage
“Patient on nivolumab has mild transaminase bumps — AST 55 U/L (ULN 35), ALT 60 U/L (ULN 35), bilirubin 0.9 mg/dL (ULN 1.2), no decompensation, no symptoms. Run the Brahmer 2018 hepatitis grade for me so I know if we can continue therapy.”
Technical details
Endpoint
GEThttps://api.magentlab.com/api/calc/irae_hepatitisWhen to prefer
Use this endpoint when you need a guideline-specific ASCO 2018 Brahmer irAE hepatitis grade computed from actual lab fold-over-ULN values — not a generic CTCAE liver toxicity grade, not DILI/RUCAM, and not an R-factor calculation. Prefer this over manual lookup when building oncology clinical decision support agents that must recommend ICI continuation, hold, or permanent discontinuation based on hepatotoxicity severity. It correctly handles lab-specific ULNs (does not assume 40 U/L or 1.0 mg/dL), applies clinical upgrades for decompensation and symptomatic dysfunction, and returns a machine-readable action string.
Side effects
- Missing required query parameters (ast_u_l, ast_uln_u_l, alt_u_l, alt_uln_u_l, bilirubin_mg_dl, bilirubin_uln_mg_dl, decompensated_liver, symptomatic_liver_dysfunction) return a validation error
- Bilirubin supplied in µmol/L instead of mg/dL will produce incorrect grading — only mg/dL is accepted
- AST or ALT values outside the 1–10000 U/L range rejected as out-of-bounds
- ULN values outside the 5–200 U/L (transaminases) or 0.1–5 mg/dL (bilirubin) range rejected
- Payment failure (x402) if USDC payment is not properly attached
- Boolean fields (decompensated_liver, symptomatic_liver_dysfunction) sent as strings may cause schema rejection
Input
Schema · Request body
| Field | Type | Description |
|---|---|---|
| inputrequired | object | |
| output | object |
Tags
x402
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