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magent irAE Nephritis Grader (ASCO 2018 Brahmer)
x402
magent irAE Nephritis Grader (ASCO 2018 Brahmer) is a paid API for AI agents from api.magentlab.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-14).
Computes ASCO 2018 Brahmer irAE nephritis grade (0–4) from creatinine vs baseline and clinical flags, and returns ICI management action (continue, consider_hold, hold, or permanently_discontinue).
Price / call$0.005
Success—
StatusUnknown
How this service works
ASCO 2018 (Brahmer) irAE nephritis grade from creatinine vs baseline (mg/dL). First-match: 4 if dialysis or life-threatening; 3 if fold >3, creatinine >=4.0, or hospitalization; 2 if fold >2; 1 if fold >=1.5 or delta >=0.3; else 0. ICI action continue (0), consider_hold (1), hold (2), permanently_discontinue (3-4). Not a medical device, not a diagnosis, not KDIGO/AKIN, not a steroid dose; magent does not assay creatinine.
Output
Returns an irAE nephritis grade integer (0–4) computed by first-match rules from the Brahmer 2018 ASCO Table 6.1 criteria (dialysis/life-threatening → 4; fold >3 or creatinine ≥4.0 or hospitalization → 3; fold >2 → 2; fold ≥1.5 or delta ≥0.3 → 1; else 0), plus a recommended ICI management action string (continue for grade 0, consider_hold for grade 1, hold for grade 2, permanently_discontinue for grades 3–4).
Example use cases
ICI hold decision for rising creatinine
“My oncology patient is on pembrolizumab and their creatinine jumped from 0.8 to 2.5 mg/dL. No dialysis needed, no life-threatening issues, and no hospitalization. What's the Brahmer irAE nephritis grade and what should we do with the immunotherapy?”
Grade 4 nephritis with dialysis
“Patient on nivolumab now requires dialysis — baseline creatinine was 1.1 mg/dL and current is 5.8 mg/dL, life-threatening situation confirmed. What is the irAE nephritis grade and the checkpoint inhibitor management action?”
Borderline creatinine elevation triage
“Our ICI patient has creatinine of 1.2 mg/dL versus a baseline of 0.8 mg/dL, no hospitalization, no dialysis, no life-threatening condition. Does this meet any irAE nephritis grade threshold and can we continue immunotherapy?”
Technical details
Endpoint
GEThttps://api.magentlab.com/api/calc/irae_nephritisWhen to prefer
Use this endpoint when you need a fast, rule-based ASCO 2018 Brahmer irAE nephritis grade and matching ICI management action derived from creatinine measurements. It is not KDIGO/AKIN staging and does not suggest steroid doses. Prefer it over manual calculation when integrating irAE nephritis grading into automated oncology workflows or clinical decision-support pipelines that already have creatinine values and caller-assessed clinical flags.
Side effects
- Missing required query parameters (creatinine_mg_dl, baseline_creatinine_mg_dl, or boolean flags) returns a 400/422 validation error
- Creatinine values outside accepted range (0.1–20 mg/dL) may be rejected or produce undefined behavior
- Units other than mg/dL (e.g. µmol/L) are not accepted and will silently produce wrong grades
- Boolean flags incorrectly set by caller lead to incorrect grading since the endpoint trusts caller-assigned clinical observations
- Network or payment (x402) authentication failures prevent any response
Input
Schema · Request body
| Field | Type | Description |
|---|---|---|
| inputrequired | object | |
| output | object |
Tags
x402
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