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magent McDonald 2024 MS Criteria Calculator
x402
magent McDonald 2024 MS Criteria Calculator is a paid API for AI agents from api.magentlab.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-14).
Evaluates 2024 McDonald criteria for relapsing-onset multiple sclerosis diagnosis based on caller-assigned clinical and paraclinical inputs
Price / call$0.005
Success—
StatusUnknown
How this service works
2024 McDonald typical CIS (Montalban 2025). mcdonald_ms iff typical_cis and no_better_explanation and: ≥2 attacks with ≥2 lesions; or ≥2 attacks with one lesion plus DIS; or CIS with ≥2 lesions plus MRI DIT, OCB, or kappa FLC; or CIS with one lesion plus DIS and MRI DIT, OCB, or kappa FLC. DIS = ≥2 of 5 topographies (optic nerve added). Kappa FLC interchangeable with OCB. Not 2017 McDonald. Not PPMS. Not RIS. magent does not read MRI or assay CSF. Not a diagnosis. Not a medical device.
Output
Returns a boolean indicating whether the 2024 McDonald criteria for relapsing-onset MS are met, along with intermediate flags for dissemination in space (DIS) and dissemination in time (DIT) satisfaction, based entirely on caller-assigned inputs. Does not perform MRI reading, CSF assay, or patient examination.
Example use cases
CIS with MRI findings MS check
“I have a patient with a typical clinically isolated syndrome, no better explanation, one attack, one lesion, but MRI shows dissemination in space (periventricular and cortical lesions positive) and dissemination in time, and CSF OCB is positive. Does this meet 2024 McDonald criteria for MS?”
Two attacks two lesions MS evaluation
“Check McDonald 2024 criteria for a patient with typical CIS, no better explanation, two or more attacks, two or more lesions, no MRI DIT, no OCB, no kappa free-light chains — periventricular and spinal cord topographies are positive. Does this patient qualify?”
Optic neuritis plus spinal cord lesion DIS check
“For a patient with typical CIS and no better explanation, one attack, one lesion, optic nerve topography positive and spinal cord topography positive but no other DIS locations, MRI DIT is positive, kappa free-light chains positive, no OCB — run the 2024 McDonald MS criteria check.”
Technical details
Endpoint
GEThttps://api.magentlab.com/api/calc/mcdonald_2024When to prefer
Choose this endpoint when you need a deterministic, formula-based evaluation of the published 2024 McDonald MS diagnostic criteria (Montalban 2025 update) for a relapsing-onset pathway, especially when optic nerve as a fifth DIS topography or kappa free-light chains as a DIT marker are relevant. Prefer over manual calculation when integrating into clinical decision support pipelines requiring reproducible, auditable outputs. Not suitable for PPMS, RIS, atypical presentations, or when MRI reading or CSF assay is needed.
Side effects
- Missing required query parameters returns a validation error
- Incorrect boolean string formats may cause parsing failure
- Endpoint does not handle PPMS, RIS, or atypical CIS — always returns false for non-typical CIS
- Caller-assigned inputs that contradict clinical reality are not validated by the API
- Network timeout or 402 payment failure if USDC payment header is missing or insufficient
Input
Schema · Request body
| Field | Type | Description |
|---|---|---|
| inputrequired | object | |
| output | object |
Tags
x402
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