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MARS (Mutation-Adjusted Risk Score) for Advanced Systemic Mastocytosis
x402
MARS (Mutation-Adjusted Risk Score) for Advanced Systemic Mastocytosis is a paid API for AI agents from api.magentlab.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-15).
Computes the Jawhar 2019 MARS prognostic integer score (0–5) for advanced systemic mastocytosis and returns OS-based risk tier (low/intermediate/high).
Price / call$0.005
Success—
StatusUnknown
How this service works
Jawhar 2019 mutation-adjusted risk score (MARS) for advanced systemic mastocytosis: age >60 (1), hemoglobin <10 g/dL (1), platelets <100×10^9/L (1), exactly one S/A/R mutation among SRSF2, ASXL1, RUNX1 (1) or two or more (2, not both). Max 5. Low 0–1 (training-set median OS not reached), intermediate 2 (3.9 y), high 3–5 (1.9 y). Not WHO SM criteria. magent does not sequence or assay labs.
Output
Returns the MARS integer total score (0–5), each component's contribution, and the corresponding risk tier: low (0–1, median OS not reached in training set), intermediate (2, ~3.9 years median OS), or high (3–5, ~1.9 years median OS). Does not perform lab assays or genetic sequencing — caller supplies all values.
Example use cases
Hematologist prognostic risk assessment
“My advanced SM patient is 72 years old, hemoglobin 9.2 g/dL, platelets 60 × 10^9/L, and has two S/A/R mutations (SRSF2 and ASXL1). What is their MARS score and risk tier?”
Treatment planning for intermediate-risk ASM
“I need to stratify a 58-year-old advanced systemic mastocytosis patient: hemoglobin is 11 g/dL, platelets are 95 × 10^9/L, and they have one SAR mutation (RUNX1). What MARS score do they get and what does that mean for survival?”
Clinical trial eligibility screening
“Screen this ASM patient for our high-risk trial arm — they're 65 years old, hemoglobin 8.0 g/dL, platelets 45 × 10^9/L, zero S/A/R mutations. Run the Jawhar MARS calculation and tell me if they fall into the high-risk group.”
Technical details
Endpoint
GEThttps://api.magentlab.com/api/calc/marsWhen to prefer
Use when you need to apply the Jawhar 2019 MARS algorithm specifically for advanced systemic mastocytosis (ASM) prognostication; this is the validated integer model incorporating S/A/R mutation burden alongside CBC parameters and age. Prefer over generic oncology risk tools when the patient has confirmed ASM and caller-assigned SRSF2/ASXL1/RUNX1 mutation status is available.
Side effects
- Missing required parameter (age, platelets_10e9_l, or sar_mutation_count) returns a validation error
- Both hemoglobin_g_l and hemoglobin_g_dl provided simultaneously triggers a conflict error
- sar_mutation_count outside 0–2 range returns a validation error
- Age outside 18–120 or platelets outside 1–2000 returns out-of-range validation error
- Boundary values (age=60, platelets=100, hemoglobin=10) score 0 per published ≤60 / ≥100 / ≥10 arm definitions
Input
Schema · Request body
| Field | Type | Description |
|---|---|---|
| inputrequired | object | |
| output | object |
Tags
x402
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