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METS-IR Calculator (Bello-Chavolla 2018)
x402
METS-IR Calculator (Bello-Chavolla 2018) is a paid API for AI agents from api.magentlab.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-13).
Computes the Metabolic Score for Insulin Resistance (METS-IR) from fasting glucose, triglycerides, HDL cholesterol, and BMI, and flags the highest T2D-risk quartile (>50.39).
Price / call$0.005
Success—
StatusUnknown
How this service works
Bello-Chavolla 2018 METS-IR: ln(2×glucose_mg_dl + triglycerides_mg_dl)×BMI / ln(HDL_mg_dl), natural log, two decimals. Supply glucose, triglycerides, and HDL each as exactly one of mg/dL or mmol/L (glucose ×18, TG ×88.57, HDL ×38.67). BMI is caller-supplied (10–80). highest_quartile_t2d is true only when METS-IR > 50.39 (derivation highest T2D-risk quartile). Not a diabetes diagnosis, not HOMA-IR/HOMA2, and not a treatment threshold.
Output
Returns the METS-IR score rounded to two decimal places, computed as ln(2×glucose_mg_dL + triglycerides_mg_dL) × BMI / ln(HDL_mg_dL), along with a boolean flag 'highest_quartile_t2d' that is true when the score exceeds 50.39 (the derivation cohort's highest T2D-risk quartile threshold).
Example use cases
Routine metabolic risk screening
“My patient has fasting glucose 102 mg/dL, triglycerides 210 mg/dL, HDL 38 mg/dL, and BMI 31.2 — what's their METS-IR score and are they in the top-risk quartile for type 2 diabetes?”
mmol/L lab values from international clinic
“We got labs back in mmol/L: glucose 5.8 mmol/L, triglycerides 2.1 mmol/L, HDL 1.05 mmol/L, and the patient's BMI is 27.4. Can you compute the METS-IR score for me?”
Longitudinal insulin resistance tracking
“Three months ago this patient had a METS-IR of 53.2. Now their fasting glucose is 88 mg/dL, triglycerides 145 mg/dL, HDL 50 mg/dL, and BMI is 26.8. What's their new METS-IR and did they drop below the 50.39 high-risk cutoff?”
Technical details
Endpoint
GEThttps://api.magentlab.com/api/calc/mets_irWhen to prefer
Use this endpoint when you need a non-insulin-based surrogate index of insulin resistance derived from a standard lipid panel and BMI, following the Bello-Chavolla 2018 derivation. Prefer it over HOMA-IR/HOMA2 when fasting insulin is unavailable. It is specifically useful for epidemiological screening or risk stratification using the >50.39 highest-quartile T2D cutoff from the original derivation study. Do not use it as a diabetes diagnosis or treatment threshold.
Side effects
- Missing required BMI parameter returns validation error
- Supplying both mg/dL and mmol/L for the same analyte returns a conflict error
- Values outside accepted ranges (e.g. BMI <10 or >80, glucose <50 or >1000 mg/dL) return a range validation error
- HDL value of zero or near-zero causes a logarithm domain error
- Missing all three lipid/glucose inputs returns an incomplete input error
Input
Schema · Request body
| Field | Type | Description |
|---|---|---|
| inputrequired | object | |
| output | object |
Tags
x402
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