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MIPSS70 Score Calculator for Primary Myelofibrosis (Guglielmelli 2018)
x402
MIPSS70 Score Calculator for Primary Myelofibrosis (Guglielmelli 2018) is a paid API for AI agents from api.magentlab.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-14).
Computes the Mutation-Enhanced International Prognostic Score System (MIPSS70) for transplant-eligible PMF patients, returning a total score, risk category, and Italian-cohort survival estimates.
Price / call$0.005
Success—
StatusUnknown
How this service works
Guglielmelli 2018 MIPSS70 for transplant-age PMF: Hb <10 g/dL (1), leukocytes >25×10^9/L (2), platelets <100×10^9/L (2), blasts ≥2% (1), fibrosis ≥2 (1), symptoms (1), no type 1/like CALR (1), HMR category (1), ≥2 HMR (2); max 12. Low 0–1, intermediate 2–4, high ≥5. Italian-cohort median (5-year) OS 27.7 y (95%), 7.1 y (70%), 2.3 y (29%). Not MIPSS70-plus or version 2.0. magent does not sequence or grade marrow.
Output
Returns a MIPSS70 integer total score (max 12), a risk category (Low: 0–1, Intermediate: 2–4, High: ≥5), and Italian-cohort survival statistics including median overall survival and 5-year OS rate (Low: 27.7 yr / 95%; Intermediate: 7.1 yr / 70%; High: 2.3 yr / 29%).
Example use cases
Pre-transplant PMF risk stratification
“I have a transplant-eligible PMF patient: Hgb 9.2 g/dL, WBC 28×10^9/L, platelets 90×10^9/L, blasts 2.5%, fibrosis grade 3, has constitutional symptoms, no type 1/like CALR mutation, and 1 HMR mutation. Run the MIPSS70 and tell me the risk group and 5-year OS.”
Monitoring disease progression over time
“My PMF patient's labs changed — now Hgb 10.5 g/dL, leukocytes 20×10^9/L, platelets 110×10^9/L, 1% blasts, grade 1 fibrosis, no symptoms, type 1 CALR mutation present, 0 HMR mutations. Recalculate the MIPSS70 score to see if the risk category improved.”
Comparing patients for transplant prioritization
“Score this PMF patient using MIPSS70 Guglielmelli 2018: hemoglobin 85 g/L, leukocytes 26×10^9/L, platelets 55×10^9/L, 4% circulating blasts, fibrosis grade 2, constitutional symptoms yes, CALR type 1/like absent, 3 or more HMR mutations — I need the total point score and the Italian cohort median OS.”
Technical details
Endpoint
GEThttps://api.magentlab.com/api/calc/mipss70When to prefer
Use this endpoint when you need the Guglielmelli 2018 MIPSS70 score specifically for transplant-age (≤70) PMF patients and have caller-assigned mutation data (CALR type, HMR count) and CBC values. Prefer this over MIPSS70-plus or version 2.0 endpoints when the original Italian-cohort survival benchmarks are required. Not suitable for post-ET/PV MF or when bone marrow grading has not yet been assigned by a pathologist.
Side effects
- Missing required query parameters (leukocytes, platelets, blasts, fibrosis grade, symptoms, CALR status, HMR count) returns validation error
- Providing both hemoglobin_g_dl and hemoglobin_g_l simultaneously causes conflict error
- Out-of-range values (e.g. blasts >30%, fibrosis grade >3, leukocytes <0.5) may trigger validation rejection
- Omitting hemoglobin entirely may return an incomplete score or error
- x402 payment failure if USDC balance is insufficient
Input
Schema · Request body
| Field | Type | Description |
|---|---|---|
| inputrequired | object | |
| output | object |
Tags
x402
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