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OpenFDA Drug Safety Profile
x402
OpenFDA Drug Safety Profile is a paid API for AI agents from openfda-drug-safety.xplowdiaka.workers.dev, paid per call via x402, $0.04/call, status unknown (last checked 2026-10-13).
Returns an FDA-sourced drug safety profile including boxed warnings, contraindications, interactions, adverse-event signals, recalls, shortage status, and pregnancy/pediatric/geriatric flags for a named US drug.
Price / call$0.04
Success—
StatusUnknown
How this service works
Drug safety profile for AI agents: given a US drug name (brand or generic), returns FDA label highlights (boxed warning, contraindications, key interactions), pregnancy/pediatric/geriatric flags, pharmacologic class, top adverse-event signals, recent recalls, current shortage status, and marketing/discontinued status. RxNorm-normalized name resolution with a confidence score. Data: openFDA (CC0). Not for clinical use.
Output
A structured JSON object containing: resolved drug identity (brand name, generic name, RxNorm CUI, NDC, resolution confidence score), FDA label highlights (boxed warning, contraindications, key interactions, mechanism of action, pharmacologic class), population flags (pregnancy, pediatric, geriatric, renal/hepatic), adverse event signals (top reactions list, percentage of serious reports), recent recalls (date, class, reason), shortage status and reason, and regulatory/marketing details (application type and number, marketing status). Includes a CC0 data disclaimer.
Example use cases
Medication safety check for patient counseling
“I'm about to counsel a patient on lisinopril — can you get me the full FDA safety profile including any boxed warnings, contraindications, the top adverse events people report, and whether it's safe during pregnancy?”
Pharmacist verifying drug interactions before dispensing
“A patient is asking about taking sertraline with their other meds — pull up the complete safety profile for sertraline so I can see all the key drug interactions and contraindications listed on the FDA label.”
Insurance prior-auth review for formulary status
“I need to verify whether atorvastatin is currently in shortage, what its FDA marketing status is, and whether there have been any recent recalls — can you grab that safety profile for me?”
Technical details
Endpoint
POSThttps://openfda-drug-safety.xplowdiaka.workers.dev/drug-safety?utm_source=zero.xyzWhen to prefer
Use this endpoint when you need a comprehensive, structured drug safety summary from FDA data sources for a named US drug — especially when you need RxNorm-normalized name resolution alongside label warnings, adverse-event signals, recall history, and shortage status in a single call. Prefer this over raw openFDA API queries when you need aggregated, pre-processed safety signals ready for agent consumption. Not suitable for clinical decision support or patient-specific dosing recommendations.
Side effects
- Drug name not recognized or cannot be resolved by RxNorm — low confidence score returned with empty candidates list
- openFDA upstream API unavailable — gateway or 5xx error
- Drug exists but has no FDA label data — null fields in label object
- Ambiguous drug name matching multiple substances — multiple candidates returned with lower confidence
- Rate limiting or payment failure at x402 layer — 402 or 429 response
Tags
x402
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