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OSIRIS Osteoporosis Index of Risk Calculator (Sedrine 2002)
x402
OSIRIS Osteoporosis Index of Risk Calculator (Sedrine 2002) is a paid API for AI agents from api.magentlab.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-14).
Computes the OSIRIS score and risk category for osteoporosis screening in postmenopausal women using age, weight, HRT status, and fracture history.
Price / call$0.005
Success—
StatusUnknown
How this service works
Sedrine 2002 Osteoporosis Index of Risk (OSIRIS). Index = (-0.2 × age) + (0.2 × weight_kg) + 2 if current HRT + (-2) if prior low-impact fracture. Risk low if score > +1, high if score < -3, intermediate otherwise including exact +1 and -3. Age 18-120; weight_kg or weight_lb; current_hrt and prior_low_impact_fracture true/false. Not a medical device, not FRAX, not a DXA order. Derivation was postmenopausal Western European women.
Output
Returns a numeric OSIRIS index value computed as (-0.2 × age) + (0.2 × weight_kg) + 2 if current HRT + (-2) if prior low-impact fracture, along with a categorical risk classification: low (score > +1), high (score < -3), or intermediate (score between -3 and +1 inclusive).
Example use cases
Pre-DXA osteoporosis triage
“I have a 72-year-old postmenopausal patient weighing 52 kg, not on HRT, who had a wrist fracture from a minor fall last year — can you calculate her OSIRIS score and tell me if she's high risk for osteoporosis?”
Routine clinic screening workflow
“Run the OSIRIS osteoporosis screening score for a 58-year-old woman, 140 lbs, currently taking estrogen, and no history of low-impact fractures — what category does she fall into?”
Assess impact of stopping HRT on risk
“My patient is 65 years old, weighs 61 kg, and just stopped hormone therapy — she has no prior fractures. What is her OSIRIS osteoporosis risk score now that she's off HRT?”
Technical details
Endpoint
GEThttps://api.magentlab.com/api/calc/osirisWhen to prefer
Use this endpoint when you need a fast, validated pre-screening score for osteoporosis risk in postmenopausal women, particularly when DXA is not yet available or to decide if DXA referral is warranted. It implements the specific Sedrine 2002 OSIRIS formula — prefer it over generic risk calculators when you need this validated index. Not appropriate as a substitute for FRAX, DXA ordering, or clinical diagnosis.
Side effects
- Missing required parameters (age, current_hrt, prior_low_impact_fracture) returns a 400 error
- Age outside 18–120 range may be rejected or produce unreliable results
- Neither weight_kg nor weight_lb provided results in an error
- Non-boolean values for current_hrt or prior_low_impact_fracture cause validation failure
- Payment failure (x402) blocks the request if USDC balance is insufficient
Input
Schema · Request body
| Field | Type | Description |
|---|---|---|
| inputrequired | object | |
| output | object |
Tags
x402
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