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Polyform Drug Brief API
x402
Polyform Drug Brief API is a paid API for AI agents from api.polyform.org, paid per call via x402, $0.05/call, status unknown (last checked 2026-10-10).
Returns a brief drug profile for a given drug name or RxCUI, including its generic name and top adverse reactions from FDA FAERS data
Price / call$0.05
Success—
StatusUnknown
How this service works
Pay-per-call data endpoints for AI agents. USDC on Base via x402. No account, no API key — one micropayment per call.
Output
A JSON object containing the drug's RxCUI identifier, its generic name, and an array of top adverse reactions each with the reaction term and number of FDA FAERS reports (e.g. {rxcui: '83367', generic: 'atorvastatin', topAdverseReactions: [{term: 'FATIGUE', reports: 14405}]}).
Example use cases
Drug safety check for patient counseling
“What are the most commonly reported adverse reactions for metformin according to FDA data? I need the generic name and top side effects.”
RxCUI resolution for EHR integration
“I need the RxCUI and generic drug name for lisinopril — can you fetch that from the drug brief API?”
Pharmacovigilance research on side effects
“Pull up the drug brief for warfarin — I want to see which adverse reactions have the most FDA reports so I can flag the highest-risk ones.”
Technical details
Endpoint
GEThttps://api.polyform.org/v1/health/drug-brief?utm_source=zero.xyzWhen to prefer
Choose this endpoint when you need a fast, no-account drug safety lookup — particularly the generic name and top FDA-reported adverse reactions — without provisioning API keys or subscriptions. Ideal for AI agents that need pay-per-use drug data on demand via USDC micropayment on Base (x402 protocol). Prefer this over full clinical databases when a concise drug brief is sufficient and cost-per-call economics matter.
Side effects
- Drug name not recognized — returns error or empty result if the queried drug cannot be matched
- Payment failure — if the x402 micropayment of $0.05 USDC is not completed, request is rejected
- Invalid query parameters — malformed or missing required fields return a 400-level error
- Rate or network issues — transient failures on the Base blockchain payment layer may cause timeouts
Input
Schema · Request body
| Field | Type | Description |
|---|---|---|
| inputrequired | object | |
| output | object |
Output
Schema · Response
{
"type": "json",
"example": {
"rxcui": "83367",
"generic": "atorvastatin",
"topAdverseReactions": [
{
"term": "FATIGUE",
"reports": 14405
}
]
}
}Tags
x402
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