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SYNTHORA MyGene.info Gene Annotation Lookup
x402
SYNTHORA MyGene.info Gene Annotation Lookup is a paid API for AI agents from mygene-gene-annotation.hergertsynthora.com, paid per call via x402, $0.001/call, status unknown (last checked 2026-09-13).
Resolves a gene symbol or query string to normalized gene annotations (Entrez ID, official name, symbol, taxon) via MyGene.info, returning scored hits ranked by relevance.
Price / call$0.001
Success—
StatusUnknown
How this service works
Resolves a gene symbol or query to normalized annotation from mygene.info/v3/query: Entrez gene ID, official name, symbol and taxonomy id across species. Autonomous agents and agent-to-agent (A2A) bioinformatics, variant-interpretation and knowledge-graph pipelines use it to canonicalize gene identifiers. Ranking surface: gene symbol to scored annotation hits. First 3 calls FREE per wallet — send header X-WALLET: 0x<addr>. No charge on upstream failure.
Output
Returns a JSON object with an 'ok' flag, a niche identifier, and a 'result' array of scored gene annotation hits. Each hit includes the official gene name, NCBI taxonomy ID, gene symbol, and Entrez gene ID. Provenance metadata (source URL and data source name) is also returned.
Example use cases
Variant interpretation pipeline gene canonicalization
“I have a variant report mentioning the gene symbol TP53 — can you resolve it to its canonical Entrez gene ID and official name for humans so I can feed it into my variant interpretation pipeline?”
Cross-species gene identifier normalization
“I need to canonicalize the gene symbol EGFR across mouse and human — look it up for species 9606 and 10090 and return the top scored annotation hits with their Entrez IDs and taxonomy IDs.”
Knowledge graph gene node enrichment
“My knowledge graph has a node labeled 'MYC' and I need its official gene name, symbol, and Entrez ID for Homo sapiens — can you fetch the top annotation hit from MyGene.info for me?”
Technical details
Endpoint
POSThttps://mygene-gene-annotation.hergertsynthora.com/serviceWhen to prefer
Choose this endpoint when an agent needs to resolve or canonicalize a gene symbol or free-text gene query into stable, normalized identifiers (Entrez ID, taxonomy ID, official symbol/name) for use in bioinformatics, variant interpretation, or knowledge graph pipelines. It is ideal when the underlying MyGene.info API is the authoritative source needed, and when species-specific filtering and ranked scoring are important. Prefer this over generic web search when structured gene annotation data is required.
Side effects
- Gene symbol not found or misspelled — returns empty results array
- Unsupported or malformed species identifier — may return no hits or mismatched results
- MyGene.info upstream service unavailable — endpoint returns error or timeout
- Query string too ambiguous — returns many low-confidence hits requiring downstream filtering
- Invalid size parameter — may return default result count or an error
Input
Schema · Request body
| Field | Type | Description |
|---|---|---|
| q | string | q |
| size | integer | size |
| species | string | species |
Output
Schema · Response
{
"type": "json",
"example": {
"ok": true,
"niche": "mygene-gene-annotation",
"result": {
"results": [
{
"name": "BRCA1 DNA repair associated",
"taxid": 9606,
"symbol": "BRCA1",
"entrezgene": "672"
}
]
},
"provenance": {
"url": "https://mygene.info/v3/query",
"source": "MyGene.info Gene Annotation Lookup"
}
}
}Tags
x402
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