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Tavaglione 2023 Fibrotic NASH Index (FNI) Calculator
x402
Tavaglione 2023 Fibrotic NASH Index (FNI) Calculator is a paid API for AI agents from api.magentlab.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-13).
Calculates the Tavaglione 2023 Fibrotic NASH Index (FNI) from AST, HbA1c, and HDL cholesterol to rule in or rule out fibrotic NASH without a liver biopsy.
Price / call$0.005
Success—
StatusUnknown
How this service works
Tavaglione 2023 fibrotic NASH index (FNI) from AST, HbA1c, and HDL cholesterol. FNI = e^x/(1+e^x) with x = -10.33 + 2.54*ln(AST) + 3.86*ln(HbA1c) - 1.66*ln(HDL mg/dL). HDL may be mg/dL or mmol/L (×38.67). Rule-out ≤0.10; indeterminate between 0.10 and 0.33; rule-in ≥0.33. Not a biopsy, not FIB-4, not the NAFLD fibrosis score, not SAFE, and not BARD.
Output
Returns a continuous FNI probability score between 0 and 1 derived from the logistic formula (e^x / (1+e^x)) with x = -10.33 + 2.54·ln(AST) + 3.86·ln(HbA1c) − 1.66·ln(HDL mg/dL). Scores ≤0.10 indicate rule-out, 0.10–0.33 are indeterminate, and ≥0.33 indicate rule-in for fibrotic NASH.
Example use cases
Pre-biopsy NASH fibrosis triage
“My patient has AST 67 U/L, HbA1c 8.2%, and HDL 42 mg/dL. Calculate their FNI score to see if I can rule out fibrotic NASH without sending them for a biopsy.”
Metabolic clinic NASH screening
“I'm reviewing a panel of metabolic syndrome patients. For this one with AST 45 U/L, HbA1c 6.9%, and HDL 1.1 mmol/L, what does the Tavaglione FNI say about their fibrotic NASH risk?”
Automated liver disease risk stratification
“As part of my hepatology workflow, compute the Fibrotic NASH Index for a patient with AST 88 U/L, HbA1c 9.1%, and HDL 33 mg/dL and tell me whether they rule in for fibrotic NASH.”
Technical details
Endpoint
GEThttps://api.magentlab.com/api/calc/fniWhen to prefer
Use this endpoint when you need a validated, formula-based non-invasive risk score specifically for fibrotic NASH (not general NAFLD fibrosis or liver fibrosis broadly). It is distinct from FIB-4, APRI, NAFLD Fibrosis Score, SAFE score, and BARD score — choose it when the clinical question is specifically whether a patient has fibrotic NASH per the Tavaglione 2023 publication. It requires only three routine blood values (AST, HbA1c, HDL) and accepts HDL in either mg/dL or mmol/L.
Side effects
- Missing required parameters (ast_u_l or a1c_percent) returns a 400 error
- Providing both hdl_mg_dl and hdl_mmol_l simultaneously causes a validation error
- Out-of-range values (e.g. AST outside 1–10000 U/L, HbA1c outside 4–15%) may return an error or undefined result
- HDL or AST of zero would cause a logarithm domain error
- Payment failure (insufficient USDC balance) returns 402 Payment Required
Input
Schema · Request body
| Field | Type | Description |
|---|---|---|
| inputrequired | object | |
| output | object |
Tags
x402
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