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Tefferi 2018 GIPSS Calculator for Primary Myelofibrosis
x402
Tefferi 2018 GIPSS Calculator for Primary Myelofibrosis is a paid API for AI agents from api.magentlab.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-09-14).
Computes the Genetically Inspired Prognostic Scoring System (GIPSS) risk score and survival category for primary myelofibrosis based on karyotype tier and four somatic mutation flags.
Price / call$0.005
Success—
StatusUnknown
How this service works
Tefferi 2018 GIPSS for primary myelofibrosis: karyotype (favorable 0, unfavorable 1, VHR 2; caller assigns the three-tier class), absence of type 1/like CALR 1, ASXL1 1, SRSF2 1, U2AF1Q157 1 (not S34); max 6. Low 0, intermediate_1 1, intermediate_2 2, high ≥3. Published median (5-year) survivals 26.4 y (94%), 8.0 y (73%), 4.2 y (40%), 2 y (14%). Not DIPSS or MIPSS70-plus. magent does not karyotype or sequence.
Output
Returns the numeric GIPSS score (0–6), the corresponding risk category (Low, Intermediate-1, Intermediate-2, or High), and published median and 5-year overall survival estimates from Tefferi 2018 (Low: 26.4 yr / 94%; Int-1: 8.0 yr / 73%; Int-2: 4.2 yr / 40%; High: 2.0 yr / 14%).
Example use cases
Newly diagnosed PMF risk stratification
“My patient just diagnosed with primary myelofibrosis has an unfavorable karyotype, no CALR type 1 mutation, ASXL1 is mutated, and SRSF2 and U2AF1 Q157 are both wild-type — can you run the Tefferi 2018 GIPSS and tell me the risk group and expected median survival?”
High-risk PMF transplant eligibility assessment
“I have a PMF patient being considered for allogeneic stem cell transplant: VHR karyotype, CALR type 1 absent, ASXL1 mutated, SRSF2 mutated, U2AF1 Q157 mutated — compute the GIPSS score and 5-year survival estimate so I can document the prognostic basis.”
Low-risk PMF watchful waiting counseling
“Can you calculate the GIPSS risk category for a PMF patient with favorable karyotype, CALR type 1/like mutation present, ASXL1 wild-type, SRSF2 wild-type, and U2AF1 Q157 wild-type? I want to confirm this is low risk and get the published median survival to discuss with them.”
Technical details
Endpoint
GEThttps://api.magentlab.com/api/calc/gipssWhen to prefer
Use this endpoint when you need the Tefferi 2018 GIPSS score specifically — i.e., when cytogenetic and molecular mutation data (CALR type 1, ASXL1, SRSF2, U2AF1 Q157) are already available and you want a purely genetics-driven PMF prognostic score, as distinct from DIPSS (which requires clinical parameters) or MIPSS70-plus (which incorporates additional clinical variables). Prefer this over manual calculation to ensure correct score mapping and published survival lookup.
Side effects
- Missing required query parameters (karyotype, calr_type1_like, asxl1_mutated, srsf2_mutated, u2af1_q157_mutated) returns a 400 error
- Invalid karyotype value outside the enum (favorable/unfavorable/vhr) returns a validation error
- Non-boolean values for mutation flags return a schema validation error
- Payment not included or insufficient USDC balance returns a 402 Payment Required response
Input
Schema · Request body
| Field | Type | Description |
|---|---|---|
| inputrequired | object | |
| output | object |
Tags
x402
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