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BIOS Literature Query API (x402)
x402
BIOS Literature Query API (x402) is a paid API for AI agents from x402.ai.bio.xyz, paid per call via x402, $0.015/call, status unknown (last checked 2026-09-14).
Queries the BIOS deep-research literature endpoint to retrieve AI-synthesized answers and cited references from scientific literature, paid via USDC micro-payment on Base.
Price / call$0.015
Success—
StatusUnknown
How this service works
Payment proxy for the BIOS Deep Research API, powered by the x402 protocol. This service wraps the BIOS deep-research endpoints with crypto micro-payments using USDC on Base. Payments are verified upfront but only settled once the research job completes. ## How it works 1. **Start a research job** — `POST /api/deep-research/start` with an x402 `PAYMENT-SIGNATURE` header. The payment is verified but not settled yet. 2. **Poll for results** — `GET /api/deep-research/{conversationId}` with an `X-SIWX` header (SIWE wallet signature). Only the wallet that paid can access results. 3. **On-demand settlement** — When polling a completed job, the payment is settled immediately and results returned. A background cron also handles batch settlement. 4. **Timeout handling** — If the payment window expires before completion, the conversation enters `timeout` status. A new payment is required to retrieve results. ## SIWX Authentication (Sign-In With X) The `GET /api/deep-research/{conversationId}` endpoint requires wallet-based authentication via EIP-4361 (SIWE). When called without a valid `X-SIWX` header, the endpoint returns `401` with a SIWE challenge. The client must sign this challenge with the same wallet that made the original payment and resend the request. The `X-SIWX` header is a base64-encoded JSON object: `{ "message": "<EIP-4361 message>", "signature": "0x..." }`. ## x402 Payment Protocol All paid endpoints return `402 Payment Required` with a `PAYMENT-REQUIRED` header when no payment is provided. The header contains the payment requirements (price, token, network) that clients use to construct a payment. See [x402 docs](https://docs.cdp.coinbase.com/x402/core-concepts/how-it-works) for details.
Output
Returns a JSON object with a synthesized natural-language answer to the research question and an array of references, each containing a URL and title of the supporting scientific paper or source.
Example use cases
Biomedical evidence synthesis for clinicians
“What does recent scientific literature say about the efficacy of GLP-1 receptor agonists for non-alcoholic fatty liver disease? Give me a summary with cited sources.”
Drug mechanism literature review
“Look up peer-reviewed research on the mechanism of action of CRISPR-Cas9 off-target effects in gene therapy and summarize the key findings with references.”
Competitive landscape research for biotech
“Find recent studies on CAR-T cell therapy for solid tumors — what progress has been made in the last few years and what are the main challenges still being studied?”
Technical details
Endpoint
POSThttps://x402.ai.bio.xyz/api/agents/literature/queryWhen to prefer
Choose this endpoint when you need AI-synthesized answers grounded in real scientific literature with citations, specifically within the biomedical and life sciences domain. It is ideal over general-purpose web search when verifiability of sources matters, or when the query requires synthesis across multiple peer-reviewed papers. Prefer it over general LLM knowledge when you need up-to-date or niche scientific references. It suits agentic workflows that can handle async polling and crypto micro-payments via the x402 protocol on Base.
Side effects
- Missing or invalid x402 PAYMENT-SIGNATURE header returns a 402 Payment Required error
- Payment window expiration causes conversation to enter timeout status, requiring a new payment to retrieve results
- Invalid or expired SIWX wallet signature on GET polling endpoint returns 401 Unauthorized
- Research job not yet completed returns a pending/in-progress status on polling
- Network or provider-side timeout for long-running deep research jobs
- Malformed query body returns 400 Bad Request
Output
Schema · Response
{
"type": "json",
"example": {
"answer": "Recent studies show...",
"references": [
{
"url": "...",
"title": "..."
}
]
}
}Tags
x402
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