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magent R-ISS Calculator
x402
magent R-ISS Calculator is a paid API for AI agents from api.magentlab.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-10-12).
Computes the Revised International Staging System (R-ISS) stage for multiple myeloma using beta-2 microglobulin, albumin, LDH status, and cytogenetic risk (Palumbo 2015).
Price / call$0.005
Success—
StatusUnknown
How this service works
Deterministic published-formula arithmetic plus ICD-10-CM, RxNorm, and LOINC. Pay in USDC on Base via x402.
Output
Returns a JSON object with the computed ISS stage (1–3) and R-ISS stage (1–3) along with their string labels, the echo of input values, the full formula expression applied, a citation to Palumbo 2015 (DOI and PMID), and a clinical disclaimer noting this is deterministic formula output and not a medical device.
Example use cases
Automated myeloma staging in clinical workflow
“Stage this myeloma patient using R-ISS: beta-2 microglobulin is 6.2 mg/L, albumin is 3.2 g/dL, LDH is above the upper limit of normal, and iFISH shows a t(4;14) translocation — so high-risk cytogenetics is true.”
Research cohort R-ISS classification
“I have a myeloma research patient with beta-2 microglobulin of 2.8 mg/L, serum albumin of 38 g/L, LDH not elevated, and no high-risk cytogenetic abnormalities — what is their ISS and R-ISS stage according to Palumbo 2015?”
Prognostic stratification at diagnosis
“For a newly diagnosed myeloma patient, beta-2 microglobulin is 5.8 mg/L, albumin is 3.8 g/dL, LDH is normal, and del(17p) is detected on FISH — compute their R-ISS stage.”
Technical details
Endpoint
GEThttps://api.magentlab.com/api/calc/r_iss?utm_source=zero.xyzWhen to prefer
Use this endpoint when you need a deterministic, citation-backed R-ISS stage computation per Palumbo 2015 for a multiple myeloma patient and you already have the serum beta-2 microglobulin, albumin, LDH-vs-ULN status, and iFISH cytogenetic risk classification in hand. Do not use if you need the R2-ISS (2022 revision), Durie-Salmon staging, or if you need laboratory assay of any of the input values — this endpoint only computes the formula, it does not perform any laboratory testing.
Side effects
- Missing required parameters (beta2_microglobulin_mg_l, high_risk_ca, or ldh_gt_uln) returns a validation error
- Beta-2 microglobulin value outside range 0.2–40 mg/L may produce an error or unexpected result
- Providing both albumin_g_l and albumin_g_dl simultaneously is disallowed and returns an error
- Albumin value outside g/dL range 1–6 or g/L range 10–60 may be rejected
- Non-boolean values for high_risk_ca or ldh_gt_uln cause type validation failure
Input
Schema · Request body
| Field | Type | Description |
|---|---|---|
| inputrequired | object | |
| output | object |
Output
Schema · Response
{
"type": "json",
"example": {
"path": "/api/calc/r_iss",
"count": 2,
"items": [
{
"formula": "r_iss",
"citation": {
"id": "palumbo-2015",
"doi": "10.1200/JCO.2015.61.2267",
"pmid": "26240224",
"title": "Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group",
"source": "J Clin Oncol. 2015;33(26):2863-2869",
"authors": "Palumbo A, Avet-Loiseau H, Oliva S, et al."
},
"iss_stage": 1,
"disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
"ldh_gt_uln": false,
"riss_stage": 1,
"albumin_g_dl": 4,
"high_risk_ca": false,
"iss_stage_label": "I",
"riss_stage_label": "I",
"formula_expression": "R-ISS I: ISS I AND high_risk_ca false AND ldh_gt_uln false; R-ISS III: ISS III AND (high_risk_ca OR ldh_gt_uln); R-ISS II: all other combinations. ISS I: beta2_microglobulin_mg_l < 3.5 AND albumin_g_dl >= 3.5; ISS III: beta2_microglobulin_mg_l >= 5.5; ISS II: neither I nor III (Palumbo 2015; ISS as Greipp 2005)",
"beta2_microglobulin_mg_l": 2
},
{
"formula": "r_iss",
"citation": {
"id": "palumbo-2015",
"doi": "10.1200/JCO.2015.61.2267",
"pmid": "26240224",
"title": "Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group",
"source": "J Clin Oncol. 2015;33(26):2863-2869",
"authors": "Palumbo A, Avet-Loiseau H, Oliva S, et al."
},
"iss_stage": 1,
"disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
"ldh_gt_uln": false,
"riss_stage": 1,
"albumin_g_dl": 4,
"high_risk_ca": false,
"iss_stage_label": "I",
"riss_stage_label": "I",
"formula_expression": "R-ISS I: ISS I AND high_risk_ca false AND ldh_gt_uln false; R-ISS III: ISS III AND (high_risk_ca OR ldh_gt_uln); R-ISS II: all other combinations. ISS I: beta2_microglobulin_mg_l < 3.5 AND albumin_g_dl >= 3.5; ISS III: beta2_microglobulin_mg_l >= 5.5; ISS II: neither I nor III (Palumbo 2015; ISS as Greipp 2005)",
"beta2_microglobulin_mg_l": 2
}
]
}
}Tags
x402
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