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bio.halowerk.com Allergen Epitope Similarity Analyzer
x402
bio.halowerk.com Allergen Epitope Similarity Analyzer is a paid API for AI agents from bio.halowerk.com, paid per call via x402, $0.004/call, status unknown (last checked 2026-09-14).
Builds amino-acid k-mer sets from a query protein sequence and known epitopes, computes Jaccard similarity, and finds the highest contiguous identity window between each epitope and the query sequence.
Price / call$0.004
Success—
StatusUnknown
How this service works
Builds amino-acid k-mer sets, calculates Jaccard similarity, and finds the highest contiguous identity between each supplied epitope and any equal-length window of the query. It does not predict immune binding, allergenicity, cross-reactivity or clinical risk and cannot replace curated databases or laboratory testing.
Output
Returns per-epitope results including Jaccard similarity score (based on k-mer set overlap) and the highest contiguous identity found between the epitope and any equal-length window in the query sequence. Does not include immune binding predictions, allergenicity risk scores, or clinical assessments.
Example use cases
Novel food protein allergenicity screening
“I've got a candidate recombinant soy protein with sequence MKTLLLTLVVVTIVCLDLGAVGNGLCCY and I want to compare it against these 12 known soy allergen epitopes using k-mer size 8 — tell me the Jaccard similarity and best contiguous identity match for each one.”
Bioinformatics pipeline epitope overlap check
“Run a k-mer comparison with k=5 between my query protein ACDEFGHIKLMNPQRSTVWYACDEF and these three reference epitopes — IDs epi001, epi002, epi003 — and give me the Jaccard scores and highest identity windows.”
Research-grade sequence similarity for epitope mapping
“I'm studying cross-reactive proteins and need to know how similar the sequence RNDEQKLMVWPFGSTYA is to each of these 20 known epitopes — use k-mer size 4 and report back the Jaccard similarity and maximum contiguous match length for every epitope.”
Technical details
Endpoint
POSThttps://bio.halowerk.com/v1/allergen-epitopeWhen to prefer
Use this endpoint when you need a fast, computational sequence-similarity comparison between a query protein and a set of known epitopes using k-mer and contiguous identity methods. It is appropriate for bioinformatics screening workflows, research pipelines, or preliminary similarity assessments — not for clinical allergenicity prediction, immune binding affinity prediction, or as a replacement for curated allergen databases.
Side effects
- Invalid amino acid characters in query_sequence or epitope sequences (must match ^[ACDEFGHIKLMNPQRSTVWY]+$)
- kmer_size outside allowed range of 2–12 returns validation error
- known_epitopes array empty or exceeds 200 items
- query_sequence or epitope sequence shorter than 2 characters
- Epitope sequence longer than 500 characters or query longer than 10000 characters
- Missing required fields (query_sequence or known_epitopes)
Input
Schema · Request body
| Field | Type | Description |
|---|---|---|
| kmer_size | integer | |
| known_epitopes | array | |
| query_sequence | string |
Tags
x402
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