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Saylor Innovations Bioinformatics: Gene Variant List by Clinical Significance (ClinVar)
x402
Saylor Innovations Bioinformatics: Gene Variant List by Clinical Significance (ClinVar) is a paid API for AI agents from saylorinnovations.com, paid per call via x402, $0.003/call, status unknown (last checked 2026-10-01).
Fetches ClinVar variants for a gene filtered by clinical significance, returning total count plus latest records with classification, review stars, conditions, and protein change
Price / call$0.003
Success—
StatusUnknown
How this service works
Gene Variant List by Clinical Significance (ClinVar). ClinVar variants for a gene, filtered by clinical significance (pathogenic, likely_pathogenic, uncertain, benign, likely_benign, conflicting): total count in ClinVar plus the latest records with classification, review stars, conditions and protein change. NCBI ClinVar, public domain.
Output
Returns a JSON object with a 'found' boolean, the total count of matching variants in ClinVar, and an array of variant records each containing clinical classification, review star rating, associated conditions, and protein change information
Example use cases
Research pathogenic BRCA2 variants
“Show me the pathogenic variants for BRCA2 from ClinVar — I want to see the classifications, how many stars each review has, what conditions they're linked to, and any protein changes listed.”
Screen uncertain significance variants
“I need to review all variants of uncertain significance for the TP53 gene in ClinVar. Can you pull the latest records with their review ratings and associated conditions?”
Compare likely benign variant counts
“How many likely benign variants does ClinVar have for CFTR? Can you also show me the most recent records with their clinical classifications and protein changes?”
Technical details
Endpoint
GEThttps://saylorinnovations.com/api/bio/variants?utm_source=zero.xyzWhen to prefer
Use this endpoint when you need structured ClinVar variant data for a specific gene filtered by clinical significance category. It is ideal for genomic research workflows, clinical decision support tools, or bioinformatics agents that need to quickly surface pathogenic, benign, or uncertain variant records without building a direct NCBI ClinVar API integration. Prefer this over raw NCBI queries when you want pre-filtered, pay-per-call simplicity with protein change and condition metadata bundled in one response.
Side effects
- Invalid or unrecognized gene symbol returns found=false with empty variants array
- Invalid significance value returns an error or empty result
- Gene with no ClinVar entries returns found=false
- NCBI ClinVar upstream outage may cause timeout or empty response
- Missing required gene parameter returns a validation error
Input
Schema · Request body
| Field | Type | Description |
|---|---|---|
| inputrequired | object | |
| output | object |
Tags
x402
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