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Reactome Biological Pathways Lookup by Gene
x402
Reactome Biological Pathways Lookup by Gene is a paid API for AI agents from saylorinnovations.com, paid per call via x402, $0.002/call, status unknown (last checked 2026-10-01).
Returns all Reactome biological pathways associated with a given gene symbol or UniProt accession, including pathway IDs, names, disease flags, and links.
Price / call$0.002
Success—
StatusUnknown
How this service works
Biological Pathways for a Gene (Reactome). Biological pathways a gene or protein takes part in (Reactome), by gene symbol or UniProt accession: every pathway with its Reactome id, name, disease flag and link. Human by default, ?organism= taxon for others. Reactome, CC BY 4.0.
Output
A list of pathways the gene or protein participates in, each including a Reactome pathway ID, human-readable pathway name, a boolean disease flag indicating whether the pathway is disease-associated, a direct Reactome link, and organism context.
Example use cases
Cancer gene pathway profiling
“I'm researching BRCA2 and need to know every Reactome pathway it participates in — especially any flagged as disease-related. Can you pull all the pathway names and IDs?”
Drug target pathway context
“Look up all Reactome pathways for EGFR so I can understand what signaling networks a drug targeting that gene would affect.”
Mouse model pathway mapping
“Can you get the Reactome pathways for the Trp53 gene in mouse — use taxon ID 10090 — and list all the pathway names and their Reactome IDs?”
Technical details
Endpoint
GEThttps://saylorinnovations.com/api/bio/pathways/:id?utm_source=zero.xyzWhen to prefer
Use this endpoint when you need structured Reactome pathway annotations for a specific gene or protein, including disease pathway flags and direct Reactome links. Prefer this over manual Reactome web queries when automating bioinformatics pipelines, enrichment analyses, or building gene-pathway knowledge graphs. It is especially useful for agents needing machine-readable pathway data with UniProt or gene symbol input without requiring direct Reactome API integration.
Side effects
- Unknown gene symbol or UniProt accession returns empty results or 404
- Invalid organism taxon ID returns error or defaults to human unexpectedly
- Network timeout for genes involved in very large numbers of pathways
- Ambiguous gene symbols that map to multiple genes may return merged or incorrect results
- Non-human organism with limited Reactome coverage may return sparse results
Tags
x402
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