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Gene Expression Lookup by Tissue (GTEx)
x402
Gene Expression Lookup by Tissue (GTEx) is a paid API for AI agents from win.oneshotagent.com, paid per call via x402, $0.01/call, status unknown (last checked 2026-10-25).
Returns median TPM expression of a human gene across normal tissues, ranked highest to lowest, using GTEx v11 data.
Price / call$0.01
Success—
StatusUnknown
How this service works
Look up median expression of a human gene across normal tissues, highest expression first.
Output
Returns a JSON object containing gene metadata (symbol, chromosome, Ensembl ID, Entrez ID, description), the unit (TPM), dataset version (gtex_v11), and an ordered array of tissues with their median TPM values and ontology IDs, sorted highest expression first.
Example use cases
Identify primary expression site for drug target
“I'm researching ACE2 as a drug target — which 10 tissues show the highest median expression of ACE2 in normal humans? Give me the TPM values.”
Verify housekeeping gene expression
“Can you pull GTEx expression data for GAPDH across all tissues? I want to confirm it's broadly and evenly expressed as a housekeeping gene.”
Profile cancer gene in normal tissue
“Look up the tissue expression profile for KRAS using its Ensembl ID ENSG00000133703 — show me the top 15 tissues with the highest median TPM.”
Technical details
Endpoint
POSThttps://win.oneshotagent.com/v1/tools/lookup/gene-expression?utm_source=zero.xyzWhen to prefer
Use this endpoint when you need authoritative, curated median expression data for a human gene across normal (non-diseased) tissues from the GTEx v11 dataset. Prefer this over RNA-seq database queries or literature lookups when you need structured, machine-readable TPM values ranked by expression level. Ideal for drug target assessment, biomarker validation, tissue specificity analysis, or any pipeline that needs normalized expression baselines.
Side effects
- Unrecognized gene symbol or Ensembl ID returns matched:false with empty tissues array
- Invalid characters in gene name return a validation error
- Limit out of range (>60 or <1) returns a schema validation error
- Network timeout for very broad queries
- Gene exists but has no GTEx data (e.g. very new genes not in v11)
Input
Schema · Request body
| Field | Type | Description |
|---|---|---|
| gene | string | Official human gene symbol (TP53) or Ensembl gene ID (ENSG00000141510), with or without a version. 1 to 30 characters. Letters, digits, ".", "_" and "-" only. |
| limit | integer | Tissues returned, highest median first; omit for all tissues. From 1 to 60. |
Output
Schema · Response
{
"type": "json",
"example": {
"gene": {
"symbol": "TP53",
"chromosome": "chr17",
"ensembl_id": "ENSG00000141510",
"gencode_id": "ENSG00000141510.19",
"description": "tumor protein p53",
"entrez_gene_id": 7157
},
"unit": "TPM",
"dataset": "gtex_v11",
"matched": true,
"tissues": [
{
"tissue": "Cells_EBV-transformed_lymphocytes",
"median_tpm": 54.4686,
"ontology_id": "EFO:0000572"
},
{
"tissue": "Skin_Sun_Exposed_Lower_leg",
"median_tpm": 25.8191,
"ontology_id": "UBERON:8480050"
}
]
}
}Tags
x402
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