UniProt Protein/Gene Symbol Resolver

x402

UniProt Protein/Gene Symbol Resolver is a paid API for AI agents from win.oneshotagent.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-10-26).

Resolves a gene symbol, synonym, entry name, or protein name to UniProt accessions and associated metadata for a given organism.

Price / call$0.005

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StatusUnknown

How this service works

Resolve a gene symbol, synonym, entry name or protein name to UniProt accessions.

Output

A JSON object containing: total match count, an ambiguous flag, and a list of matches each with UniProt accession, entry name, protein name, gene name and synonyms, organism (taxon ID and scientific name), annotation score (0–5), reviewed status, matched field, and a direct UniProt entry page URL.

Example use cases

Gene-to-accession for drug target pipeline

“I need the UniProt accession for BRCA2 in human — reviewed entries only, give me up to 5 matches so I can pick the right isoform.”

Cross-species protein ID lookup

“What's the UniProt accession for Trp53 in mouse (taxon 10090)? Include unreviewed entries and return up to 3 results.”

Protein name to accession for data annotation

“Resolve the protein name 'Cellular tumor antigen p53' to its UniProt accession for Homo sapiens — just the top reviewed match.”

Technical details

Endpoint

POSThttps://win.oneshotagent.com/v1/tools/resolve/protein?utm_source=zero.xyz

When to prefer

Use this endpoint when you need to translate a human-readable gene symbol, protein name, or entry name into a canonical UniProt accession — particularly when building bioinformatics pipelines, annotating datasets, or resolving identifiers before downstream database queries. It is preferable to manual UniProt search when automation or agent orchestration is required, and supports filtering by organism and review status for precision.

Side effects

Query with disallowed characters or out-of-range length returns validation error
taxon_id outside 1–999999999 range is rejected
limit outside 1–10 range is rejected
Gene symbol not found for the specified taxon returns empty matches array
Ambiguous query may return multiple unrelated proteins (ambiguous: true)
Payment failure via x402 prevents endpoint access

Input

Schema · Request body

Field	Type	Description
limit	integer	The most matches to return. From 1 to 10. Defaults to `5`.
query	string	A gene symbol or synonym, entry name, or protein name; letters, digits, spaces and the characters . _ / - only. 1 to 60 characters.
taxon_id	integer	The organism taxonomy ID; human (9606) by default. From 1 to 999999999. Defaults to `9606`.
reviewed_only	boolean	Only reviewed entries; false includes unreviewed entries. Defaults to `true`.

Output

Schema · Response

{
  "type": "json",
  "example": {
    "total": 1,
    "matches": [
      {
        "gene": "TP53",
        "organism": {
          "taxon_id": 9606,
          "scientific_name": "Homo sapiens"
        },
        "page_url": "https://www.uniprot.org/uniprotkb/P04637/entry",
        "reviewed": true,
        "accession": "P04637",
        "entry_name": "P53_HUMAN",
        "matched_on": "gene",
        "protein_name": "Cellular tumor antigen p53",
        "gene_synonyms": [
          "P53"
        ],
        "annotation_score": 5
      }
    ],
    "ambiguous": false
  }
}

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