ClinVar Gene Variant Finder

x402

ClinVar Gene Variant Finder is a paid API for AI agents from win.oneshotagent.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-10-20).

Returns ClinVar variants associated with a human gene, filterable by clinical classification and review status, given an NCBI Gene ID or official gene symbol.

Price / call$0.005

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StatusUnknown

How this service works

Find ClinVar variants in a human gene by NCBI Gene ID or official symbol.

Output

A list of ClinVar variant records associated with the specified human gene, each including variant identity, clinical classification, and review details. Results are constrained by the requested limit and any applied filters such as classification category or expert panel review status.

Example use cases

Oncology variant review for BRCA1

“Pull up to 15 pathogenic or likely pathogenic ClinVar variants for BRCA1, and only include ones that have been reviewed by an expert panel.”

Research filtering for uncertain variants in TP53

“Find ClinVar variants in TP53 classified as uncertain significance — give me up to 20 results and include variants that span multiple genes.”

Clinical screening for CFTR benign variants

“Look up benign ClinVar variants for NCBI Gene ID 1080, limit to 5 results, expert panel only.”

Technical details

Endpoint

POSThttps://win.oneshotagent.com/v1/tools/find/gene-variants?utm_source=zero.xyz

When to prefer

Use this endpoint when you need to enumerate ClinVar variants for a known human gene by symbol or NCBI Gene ID, especially with filtering by clinical significance or expert panel review. Prefer this over general variant lookup endpoints when your starting point is a gene identifier rather than an HGVS expression or rsID. For resolving aliases or non-standard gene names, use the companion gene_resolve endpoint first.

Side effects

Invalid or non-existent gene symbol returns empty result or error
Supplying both gene_id and symbol simultaneously may cause ambiguous request error
Classification enum value mismatch returns validation error
Limit out of range (below 1 or above 20) returns validation error
Gene with no ClinVar entries returns empty list
Network or upstream NCBI ClinVar unavailability causes timeout or 503 error

Input

Schema · Request body

Field	Type	Description
limit	integer	Maximum number of variants returned. From 1 to 20. Defaults to `10`.
symbol	string	Official human gene symbol, for example BRCA1; use gene_resolve for aliases. 1 to 30 characters.
gene_id	string	NCBI Gene ID, for example 672; supply exactly one of gene_id or symbol. 1 to 12 characters.
classification	string	ClinVar classification property filter; may include combined classifications
expert_panel_only	boolean	Only variants reviewed by an expert panel. Defaults to `false`.
include_multi_gene	boolean	Include variants spanning multiple genes. Defaults to `false`.

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